caa a22 4500 467907145 CHVBK 20180406152837.0 cr unu---uuuuu 170328e20061201xx s 000 0 eng 10.1007/s00251-006-0159-5 doi (NATIONALLICENCE)springer-10.1007/s00251-006-0159-5 Genetic variants of the IgA Fc receptor (FcαR, CD89) promoter in chronic hepatitis C patients [Elektronische Daten] [Azuma Watanabe, Toshibumi Shimokawa, Mitsuhiko Moriyama, Fumihiko Komine, Shuichi Amaki, Yasuyuki Arakawa, Chisei Ra] Fc receptor for IgA (FcαR, CD89) is capable of triggering IgA-mediated immune responses to pathogens and has been proposed to function in circulating IgA clearance. Because inheritable variations modifying individual immune responses or immunoglobulin catabolism may affect the chronicity of viral infection, we investigated whether promoter polymorphisms of the FcαR gene (FCAR) affect chronic hepatitis C virus (HCV) infection and its disease progression. The two −311T/C and −142T/C single-nucleotide polymorphisms (SNPs) were studied by direct DNA sequencing in 177 Japanese patients with chronic hepatitis C (CHC). Both −311CC and −142CC genotypes were more frequent in CHC patients (15.9 and 18.6%) compared with 210 healthy controls (5.7 and 10.0%) [p = 0.001, odds ratio (OR) = 3.10, 95% confidence interval CI) = 1.53-6.30 and p = 0.014, OR = 2.06, 95% CI = 1.14-3.72, respectively], and were associated with infection with HCV genotype 2a/2b (p = 0.019 and p = 0.005, respectively). Conversely, −311CC and −142CC were decreased in 59 patients at advanced stages of disease as assessed on the basis of hepatic fibrosis markers such as decreased platelet count (PLT) ( < 150,000/μl) (5.1 and 8.5%) compared with 91 patients with normal PLT ( ≥ 150,000/μl) (24.2 and 26.4%) (p = 0.006 and p = 0.005, respectively). Moreover, among the patients with normal PLT (but not with decreased PLT), −311CC or −142CC was significantly associated with decreased serum IgA levels (p = 0.023 or p = 0.007, respectively). These results suggest that the FCAR promoter SNPs may be related to chronic HCV infection and disease progression in Japanese CHC, which might be explained by altered FcαR expression affecting IgA-mediated immune responses and/or IgA catabolism. Springer-Verlag, 2006 Fc receptor nationallicence IgA nationallicence Single-nucleotide polymorphism nationallicence Chronic hepatitis C nationallicence Promoter nationallicence Watanabe Azuma Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, 30-1 Oyaguchi-kamimachi, Itabashi-ku, 173-8610, Tokyo, Japan aut Shimokawa Toshibumi Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, 30-1 Oyaguchi-kamimachi, Itabashi-ku, 173-8610, Tokyo, Japan aut Moriyama Mitsuhiko Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan aut Komine Fumihiko Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan aut Amaki Shuichi Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan aut Arakawa Yasuyuki Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan aut Ra Chisei Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, 30-1 Oyaguchi-kamimachi, Itabashi-ku, 173-8610, Tokyo, Japan aut Immunogenetics Springer-Verlag 58/12(2006-12-01), 937-946 0093-7711 58:12<937 2006 58 251 https://doi.org/10.1007/s00251-006-0159-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-006-0159-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Watanabe Azuma Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, 30-1 Oyaguchi-kamimachi, Itabashi-ku, 173-8610, Tokyo, Japan aut NATIONALLICENCE 700 1- Shimokawa Toshibumi Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, 30-1 Oyaguchi-kamimachi, Itabashi-ku, 173-8610, Tokyo, Japan aut NATIONALLICENCE 700 1- Moriyama Mitsuhiko Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Komine Fumihiko Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Amaki Shuichi Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Arakawa Yasuyuki Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Ra Chisei Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, 30-1 Oyaguchi-kamimachi, Itabashi-ku, 173-8610, Tokyo, Japan aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/12(2006-12-01), 937-946 0093-7711 58:12<937 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer