caa a22 4500 467907161 CHVBK 20180406152837.0 cr unu---uuuuu 170328e20061201xx s 000 0 eng 10.1007/s00251-006-0166-6 doi (NATIONALLICENCE)springer-10.1007/s00251-006-0166-6 Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques [Elektronische Daten] [Andrea Weiler, Gemma May, Ying Qi, Nancy Wilson, David Watkins] Polymorphisms in several host genes in HIV-infected individuals facilitate slow progression to AIDS. We have identified several SIV-infected Indian rhesus macaques that naturally control viral replication. We investigated whether spontaneous control of SIV in any of these animals could be explained by mutations in host genes. Such variables could confound studies of associations between MHC class I alleles and control of viral replication. We searched for polymorphisms in CCR5, CXCR6, GPR15, RANTES, IL-10, APOBEC3G, TNF-α, and TSG101 and looked for associations with decreased viral replication. We did not detect any correlations between plasma viral concentration and polymorphisms in host genes examined in this study. In addition, we did not find the polymorphisms present in humans in any of our macaques. Springer-Verlag, 2006 Genetic polymorphism nationallicence AIDS progression nationallicence Rhesus macaque nationallicence Weiler Andrea Wisconsin National Primate Research Center, University of Wisconsin-Madison, 53715, Madison, WI, USA aut May Gemma Wisconsin National Primate Research Center, University of Wisconsin-Madison, 53715, Madison, WI, USA aut Qi Ying Laboratory of Genomic Diversity, SAIC-Frederick, Incorporated, NCI-Frederick, 21702, Frederick, MD, USA aut Wilson Nancy Wisconsin National Primate Research Center, University of Wisconsin-Madison, 53715, Madison, WI, USA aut Watkins David Wisconsin National Primate Research Center, University of Wisconsin-Madison, 53715, Madison, WI, USA aut Immunogenetics Springer-Verlag 58/12(2006-12-01), 1003-1009 0093-7711 58:12<1003 2006 58 251 https://doi.org/10.1007/s00251-006-0166-6 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-006-0166-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Weiler Andrea Wisconsin National Primate Research Center, University of Wisconsin-Madison, 53715, Madison, WI, USA aut NATIONALLICENCE 700 1- May Gemma Wisconsin National Primate Research Center, University of Wisconsin-Madison, 53715, Madison, WI, USA aut NATIONALLICENCE 700 1- Qi Ying Laboratory of Genomic Diversity, SAIC-Frederick, Incorporated, NCI-Frederick, 21702, Frederick, MD, USA aut NATIONALLICENCE 700 1- Wilson Nancy Wisconsin National Primate Research Center, University of Wisconsin-Madison, 53715, Madison, WI, USA aut NATIONALLICENCE 700 1- Watkins David Wisconsin National Primate Research Center, University of Wisconsin-Madison, 53715, Madison, WI, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/12(2006-12-01), 1003-1009 0093-7711 58:12<1003 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer