caa a22 4500 467907218 CHVBK 20180406152838.0 cr unu---uuuuu 170328e20061001xx s 000 0 eng 10.1007/s00251-006-0148-8 doi (NATIONALLICENCE)springer-10.1007/s00251-006-0148-8 Hughes Austin Department of Biological Sciences, University of South Carolina, Coker Life Sciences Bldg. 700 Sumter St., 29208, Columbia, SC, USA aut Evolutionary relationships of vertebrate NACHT domain-containing proteins [Elektronische Daten] [Austin Hughes] Phylogenetic analyses of conserved [neuronal apoptosis inhibitory protein (NAIP), MHC class II transcription activator (CIITA), incompatibility locus protein from Podospora anserina (HET-E), and telomerase-associated protein (TP1)] (NACHT) domains were used to reconstruct the evolutionary history of vertebrate NACHT-containing proteins. The results supported the hypothesis that NOD3 is basal to the other NACHT-containing proteins found in tetrapods. The latter formed two strongly supported clusters or subfamilies, here designated NALP and nucleotide-binding oligomerization domain (NOD). The presence of apparent bony fish orthologs of NOD3 and CIITA supported the hypothesis that the origin of these molecules predates the origin of tetrapods, and the presence of avian sequences in both NALP and NOD clusters supported the origin of these subfamilies before the bird-mammal divergence. However, the extensive diversification of the NALP subfamily seen in mammals evidently occurred within the mammalian lineage. Both NALP and NOD subfamilies include members with differential expression in the antigen-presenting cells of the immune system, and the phylogenetic analyses supported the hypothesis that this expression pattern has evolved independently more than once in each of these subfamilies. Springer-Verlag, 2006 Immune system evolution nationallicence NACHT nationallicence NALP nationallicence NOD nationallicence Immunogenetics Springer-Verlag 58/10(2006-10-01), 785-791 0093-7711 58:10<785 2006 58 251 https://doi.org/10.1007/s00251-006-0148-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-006-0148-8 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hughes Austin Department of Biological Sciences, University of South Carolina, Coker Life Sciences Bldg. 700 Sumter St., 29208, Columbia, SC, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/10(2006-10-01), 785-791 0093-7711 58:10<785 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer