caa a22 4500 467907315 CHVBK 20180406152838.0 cr unu---uuuuu 170328e20060601xx s 000 0 eng 10.1007/s00251-006-0112-7 doi (NATIONALLICENCE)springer-10.1007/s00251-006-0112-7 Ancient divergence of a complex family of immune-type receptor genes [Elektronische Daten] [John Cannon, Robert Haire, M. Mueller, Ronda Litman, Donna Eason, Deborah Tinnemore, Chris Amemiya, Tatsuya Ota, Gary Litman] Multigene families of activating/inhibitory receptors belonging to the immunoglobulin superfamily (IgSF) regulate immunological and other cell-cell interactions. A new family of such genes, termed modular domain immune-type receptors (MDIRs), has been identified in the clearnose skate (Raja eglanteria), a phylogenetically ancient vertebrate. At least five different major forms of predicted MDIR proteins are comprised of four different subfamilies of IgSF ectodomains of the intermediate (I)- or C2-set. The predicted number of individual IgSF ectodomains in MDIRs varies from one to six. MDIR1 contains a positively charged transmembrane residue and MDIR2 and MDIR3 each possesses at least one immunoreceptor tyrosine-based inhibitory motif in their cytoplasmic regions. MDIR4 and MDIR5 lack characteristic activating/inhibitory signalling motifs. MDIRs are encoded in a particularly large and complex multigene family. MDIR domains exhibit distant sequence similarity to mammalian CMRF-35-like molecules, polymeric immunoglobulin receptors, triggering receptors expressed on myeloid cells (TREMs), TREM-like transcripts, NKp44 and FcR homologs, as well as to sequences identified in several different vertebrate genomes. Phylogenetic analyses suggest that MDIRs are representative members of an extended family of IgSF genes that diverged before or very early in evolution of the vertebrates and subsequently came to occupy multiple, fully independent distributions in the present day. Springer-Verlag, 2006 Ig superfamily nationallicence Evolution nationallicence Activating/inhibitory signalling nationallicence Cannon John Department of Pediatrics, University of South Florida College of Medicine, and USF/ACH Children's Research Institute, 830 First Street South, 33701, St. Petersburg, FL, USA aut Haire Robert Department of Pediatrics, University of South Florida College of Medicine, and USF/ACH Children's Research Institute, 830 First Street South, 33701, St. Petersburg, FL, USA aut Mueller M. Department of Molecular Genetics, All Children's Hospital, 801 Sixth Street South, 33701, St. Petersburg, FL, USA aut Litman Ronda Department of Pediatrics, University of South Florida College of Medicine, and USF/ACH Children's Research Institute, 830 First Street South, 33701, St. Petersburg, FL, USA aut Eason Donna Department of Pediatrics, University of South Florida College of Medicine, and USF/ACH Children's Research Institute, 830 First Street South, 33701, St. Petersburg, FL, USA aut Tinnemore Deborah Molecular Genetics Program, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, 98101, Seattle, WA, USA aut Amemiya Chris Molecular Genetics Program, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, 98101, Seattle, WA, USA aut Ota Tatsuya Department of Biosystems Science and Hayama Center for Advanced Studies, The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa 240-0193, Japan aut Litman Gary Department of Pediatrics, University of South Florida College of Medicine, and USF/ACH Children's Research Institute, 830 First Street South, 33701, St. Petersburg, FL, USA aut Immunogenetics Springer-Verlag 58/5-6(2006-06-01), 362-373 0093-7711 58:5-6<362 2006 58 251 https://doi.org/10.1007/s00251-006-0112-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-006-0112-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cannon John Department of Pediatrics, University of South Florida College of Medicine, and USF/ACH Children's Research Institute, 830 First Street South, 33701, St. Petersburg, FL, USA aut NATIONALLICENCE 700 1- Haire Robert Department of Pediatrics, University of South Florida College of Medicine, and USF/ACH Children's Research Institute, 830 First Street South, 33701, St. Petersburg, FL, USA aut NATIONALLICENCE 700 1- Mueller M. Department of Molecular Genetics, All Children's Hospital, 801 Sixth Street South, 33701, St. Petersburg, FL, USA aut NATIONALLICENCE 700 1- Litman Ronda Department of Pediatrics, University of South Florida College of Medicine, and USF/ACH Children's Research Institute, 830 First Street South, 33701, St. Petersburg, FL, USA aut NATIONALLICENCE 700 1- Eason Donna Department of Pediatrics, University of South Florida College of Medicine, and USF/ACH Children's Research Institute, 830 First Street South, 33701, St. Petersburg, FL, USA aut NATIONALLICENCE 700 1- Tinnemore Deborah Molecular Genetics Program, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, 98101, Seattle, WA, USA aut NATIONALLICENCE 700 1- Amemiya Chris Molecular Genetics Program, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, 98101, Seattle, WA, USA aut NATIONALLICENCE 700 1- Ota Tatsuya Department of Biosystems Science and Hayama Center for Advanced Studies, The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa 240-0193, Japan aut NATIONALLICENCE 700 1- Litman Gary Department of Pediatrics, University of South Florida College of Medicine, and USF/ACH Children's Research Institute, 830 First Street South, 33701, St. Petersburg, FL, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/5-6(2006-06-01), 362-373 0093-7711 58:5-6<362 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer