caa a22 4500 467907366 CHVBK 20180406152838.0 cr unu---uuuuu 170328e20060601xx s 000 0 eng 10.1007/s00251-006-0118-1 doi (NATIONALLICENCE)springer-10.1007/s00251-006-0118-1 Implications of inter-population linkage disequilibrium patterns on the approach to a disease association study in the human MHC class III [Elektronische Daten] [Neil Hanchard, Mahamadou Diakite, Oliver Koch, Brendan Keating, Margaret Pinder, Muminatou Jallow, Fatou Sisay-Joof, Anastasia Nijnik, Jonathan Wilson, Irina Udalova, Dominic Kwiatkowski, Kirk Rockett] There is presently much interest in utilizing patterns of linkage disequilibrium (LD) to further genetic association studies. This is particularly pertinent in the class III region of the human major histocompatibility complex (MHC), which has been extensively studied as a disease susceptibility locus in a number of ethnic groups. To date, however, few studies of LD in the MHC have considered non-Caucasian populations. With the advent of large-scale haplotyping of the human genome, the question of utilizing LD patterns across populations has come to the fore. We have previously used LD mapping to direct an MHC class III association study in a UK Caucasian population. As an extension of this, we sought to determine to what extent the pattern of LD observed in that study could be used to conduct a similar study in a West African Gambian population. We found that broad patterns of LD were similar in the two populations, resulting in similar candidate region delineations, but at a higher resolution, marker-specific patterns of LD and population-dependent allele frequencies confounded the choice of regional tagging SNPs. Our results have implications for the applicability of large-scale haplotype maps such as the HapMap to complex regions like the MHC. Springer-Verlag, 2006 Population nationallicence Linkage Disequilibrium nationallicence MHC class III nationallicence Hanchard Neil Wellcome Trust Centre for Human Genetics, Oxford, UK aut Diakite Mahamadou Wellcome Trust Centre for Human Genetics, Oxford, UK aut Koch Oliver Wellcome Trust Centre for Human Genetics, Oxford, UK aut Keating Brendan Wellcome Trust Centre for Human Genetics, Oxford, UK aut Pinder Margaret MRC Laboratories, Fajara, The Gambia aut Jallow Muminatou MRC Laboratories, Fajara, The Gambia aut Sisay-Joof Fatou MRC Laboratories, Fajara, The Gambia aut Nijnik Anastasia Wellcome Trust Centre for Human Genetics, Oxford, UK aut Wilson Jonathan Wellcome Trust Centre for Human Genetics, Oxford, UK aut Udalova Irina Wellcome Trust Centre for Human Genetics, Oxford, UK aut Kwiatkowski Dominic Wellcome Trust Centre for Human Genetics, Oxford, UK aut Rockett Kirk Wellcome Trust Centre for Human Genetics, Oxford, UK aut Immunogenetics Springer-Verlag 58/5-6(2006-06-01), 465-470 0093-7711 58:5-6<465 2006 58 251 https://doi.org/10.1007/s00251-006-0118-1 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-006-0118-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hanchard Neil Wellcome Trust Centre for Human Genetics, Oxford, UK aut NATIONALLICENCE 700 1- Diakite Mahamadou Wellcome Trust Centre for Human Genetics, Oxford, UK aut NATIONALLICENCE 700 1- Koch Oliver Wellcome Trust Centre for Human Genetics, Oxford, UK aut NATIONALLICENCE 700 1- Keating Brendan Wellcome Trust Centre for Human Genetics, Oxford, UK aut NATIONALLICENCE 700 1- Pinder Margaret MRC Laboratories, Fajara, The Gambia aut NATIONALLICENCE 700 1- Jallow Muminatou MRC Laboratories, Fajara, The Gambia aut NATIONALLICENCE 700 1- Sisay-Joof Fatou MRC Laboratories, Fajara, The Gambia aut NATIONALLICENCE 700 1- Nijnik Anastasia Wellcome Trust Centre for Human Genetics, Oxford, UK aut NATIONALLICENCE 700 1- Wilson Jonathan Wellcome Trust Centre for Human Genetics, Oxford, UK aut NATIONALLICENCE 700 1- Udalova Irina Wellcome Trust Centre for Human Genetics, Oxford, UK aut NATIONALLICENCE 700 1- Kwiatkowski Dominic Wellcome Trust Centre for Human Genetics, Oxford, UK aut NATIONALLICENCE 700 1- Rockett Kirk Wellcome Trust Centre for Human Genetics, Oxford, UK aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/5-6(2006-06-01), 465-470 0093-7711 58:5-6<465 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer