caa a22 4500 467907420 CHVBK 20180406152838.0 cr unu---uuuuu 170328e20060601xx s 000 0 eng 10.1007/s00251-006-0110-9 doi (NATIONALLICENCE)springer-10.1007/s00251-006-0110-9 Identification of a single killer immunoglobulin-like receptor (KIR) gene in the porcine leukocyte receptor complex on chromosome 6q [Elektronische Daten] [Jennifer Sambrook, Harminder Sehra, Penny Coggill, Sean Humphray, Sophie Palmer, Sarah Sims, Haru-Hisa Takamatsu, Thomas Wileman, Alan Archibald, Stephan Beck] Human killer immunoglobulin-like receptors (KIR) are expressed on natural killer (NK) cells and are involved in their immunoreactivity. While KIR with a long cytoplasmic tail deliver an inhibitory signal when bound to their respective major histocompatibility complex class I ligands, KIR with a short cytoplasmic tail can activate NK responses. The expansion of the KIR gene family originally appeared to be a phenomenon restricted to primates (human, apes, and monkeys) in comparison to rodents, which via convergent evolution have numerous C-type lectin-like Ly49 molecules that function analogously. Further studies have shown that multiple KIR are also present in cow and horse. In this study, we have identified by comparative genomics the first and possibly only KIR gene, named KIR2DL1, in the domesticated pig (Sus scrofa) allowing further evolutionary comparisons to be made. It encodes a protein with two extracellular immunoglobulin domains (D0 + D2), and a long cytoplasmic tail containing two inhibitory motifs. We have mapped the pig KIR2DL1 gene to chromosome 6q. Flanked by LILRa, LILRb, and LILRc, members of the leukocyte immunoglobulin-like receptor (LILR) family, on the centromeric end, and FCAR, NCR1, NALP7, NALP2, and GP6 on the telomeric end, pig demonstrates conservation of synteny with the human leukocyte receptor complex (LRC). Both the porcine KIR and LILR genes have diverged sufficiently to no longer be clearly orthologous with known human LRC family members. Springer-Verlag, 2006 Killer immunoglobulin-like receptor (KIR) nationallicence Leukocyte receptor complex (LRC) nationallicence Natural killer (NK) cells nationallicence Pig nationallicence Sambrook Jennifer The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut Sehra Harminder The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut Coggill Penny The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut Humphray Sean The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut Palmer Sophie The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut Sims Sarah The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut Takamatsu Haru-Hisa Institute for Animal Health, Pirbright Laboratories, GU24 ONF, Woking, England, UK aut Wileman Thomas School of Medicine, Health Policy and Practice, University of East Anglia, NR4 7TJ, Norwich, England, UK aut Archibald Alan Roslin Institute (Edinburgh), Roslin, EH25 9PS, Midlothian, Scotland, UK aut Beck Stephan The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut Immunogenetics Springer-Verlag 58/5-6(2006-06-01), 481-486 0093-7711 58:5-6<481 2006 58 251 https://doi.org/10.1007/s00251-006-0110-9 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-006-0110-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sambrook Jennifer The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut NATIONALLICENCE 700 1- Sehra Harminder The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut NATIONALLICENCE 700 1- Coggill Penny The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut NATIONALLICENCE 700 1- Humphray Sean The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut NATIONALLICENCE 700 1- Palmer Sophie The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut NATIONALLICENCE 700 1- Sims Sarah The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut NATIONALLICENCE 700 1- Takamatsu Haru-Hisa Institute for Animal Health, Pirbright Laboratories, GU24 ONF, Woking, England, UK aut NATIONALLICENCE 700 1- Wileman Thomas School of Medicine, Health Policy and Practice, University of East Anglia, NR4 7TJ, Norwich, England, UK aut NATIONALLICENCE 700 1- Archibald Alan Roslin Institute (Edinburgh), Roslin, EH25 9PS, Midlothian, Scotland, UK aut NATIONALLICENCE 700 1- Beck Stephan The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, England, UK aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/5-6(2006-06-01), 481-486 0093-7711 58:5-6<481 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer