caa a22 4500 467907498 CHVBK 20180406152838.0 cr unu---uuuuu 170328e20060501xx s 000 0 eng 10.1007/s00251-006-0083-8 doi (NATIONALLICENCE)springer-10.1007/s00251-006-0083-8 Extensive sharing of MHC class II alleles between rhesus and cynomolgus macaques [Elektronische Daten] [Gaby Doxiadis, Annemiek Rouweler, Natasja de Groot, Annet Louwerse, Nel Otting, Ernst Verschoor, Ronald Bontrop] In contrast to rhesus monkeys, substantial knowledge on cynomolgus monkey major histocompatibility complex (MHC) class II haplotypes is lacking. Therefore, 17 animals, including one pedigreed family, were thoroughly characterized for polymorphic Mhc class II region genes as well as their mitochondrial DNA (mtDNA) sequences. Different cynomolgus macaque populations appear to exhibit unique mtDNA profiles reflecting their geographic origin. Within the present panel, 10 Mafa-DPB1, 14 Mafa-DQA1, 12 Mafa-DQB1, and 35 Mafa-DRB exon 2 sequences were identified. All of these alleles cluster into lineages that were previously described for rhesus macaques. Moreover, about half of the Mafa-DPB1, Mafa-DQA1, and Mafa-DQB1 alleles and one third of the Mafa-DRB exon 2 sequences are identical to rhesus macaque orthologues. Such a high level of Mhc class II allele sharing has not been reported for primate species. Pedigree analysis allowed the characterization of nine distinct Mafa class II haplotypes, and seven additional ones could be deduced. Two of these haplotypes harbor a duplication of the Mafa-DQB1 locus. Despite extensive allele sharing, rhesus and cynomolgus monkeys do not appear to possess identical Mhc class II haplotypes, thus illustrating that new haplotypes were generated after speciation by recombination-like processes. Springer-Verlag, 2006 MHC nationallicence Nonhuman primates nationallicence Evolution nationallicence Comparative immunology nationallicence Doxiadis Gaby Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut Rouweler Annemiek Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut de Groot Natasja Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut Louwerse Annet Department of Animal Science, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut Otting Nel Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut Verschoor Ernst Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut Bontrop Ronald Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut Immunogenetics Springer-Verlag 58/4(2006-05-01), 259-268 0093-7711 58:4<259 2006 58 251 https://doi.org/10.1007/s00251-006-0083-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-006-0083-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Doxiadis Gaby Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut NATIONALLICENCE 700 1- Rouweler Annemiek Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut NATIONALLICENCE 700 1- de Groot Natasja Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut NATIONALLICENCE 700 1- Louwerse Annet Department of Animal Science, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut NATIONALLICENCE 700 1- Otting Nel Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut NATIONALLICENCE 700 1- Verschoor Ernst Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut NATIONALLICENCE 700 1- Bontrop Ronald Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/4(2006-05-01), 259-268 0093-7711 58:4<259 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer