caa a22 4500 467907722 CHVBK 20180406152839.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00251-006-0161-y doi (NATIONALLICENCE)springer-10.1007/s00251-006-0161-y Association of interferon-gamma gene haplotype in the Chinese population with hepatitis B virus infection [Elektronische Daten] [Meiqiang Liu, Bangwei Cao, Hongkun Zhang, Yue Dai, Xiaolin Liu, Changqing Xu] In general, cytokines encoded by different genes of human genome might strongly influence host cell-mediated immune responses, which play an important role in the clearance of virus by the infected host. Interferon gamma (IFN-gamma) produced by T lymphocytes and natural killer cells plays an essential role in affecting cellular immune responses. A functional study demonstrated that two single nucleotide polymorphisms located in the IFN-gamma gene intron (at positions +874 and +2109) were involved in its transcriptional regulation. The aim of this study was to evaluate whether IFN-gamma gene polymorphisms or its haplotypes might be associated with predisposition to hepatitis B virus (HBV) infection in the Chinese population. The study included 181 cases with HBV infection and 272 gender, age-matched healthy controls. All genotyping were identified by polymerase chain reaction in association with the measurement of amplification refractory mutation system. A significant difference was observed between case and control groups. The frequency of +874A allele was significantly higher in patients than in controls (OR = 2.25, 95%CI = 1.69-2.99, P < 0.0001). However, no significant difference was found in the allelic frequencies of IFN-gamma +2109A/G between cases and controls (P > 0.05). By haplotype analysis, the frequency of haplotype AG (+874A and +2109G) revealed a significant difference in the cases in comparison to controls (P < 0.0001). Multiple logistic regression analysis showed that individuals possessing haplotype AG had an increased likelihood of HBV infection (OR = 8.14, 95%CI = 4.98-13.30). Our results suggest that haplotype AG containing +874A and +2109G may be a crucial risk factor of genetic susceptibility to HBV infection in the Chinese population. Springer-Verlag, 2006 Hepatitis B virus nationallicence IFN-gamma nationallicence Haplotype nationallicence Liu Meiqiang Medical College, Shandong University, Jinan, Shandong Province, China aut Cao Bangwei Department of Anti-infection, Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China aut Zhang Hongkun Medical College, Shandong University, Jinan, Shandong Province, China aut Dai Yue Department of Blood Transfusion, Peking University First Hospital, Beijing, China aut Liu Xiaolin Medical College, Shandong University, Jinan, Shandong Province, China aut Xu Changqing Qianfoshan Hospital, No. 66 Jing Shi Road, LiXia District, 250014, Jinan, Shandong Province, China aut Immunogenetics Springer-Verlag 58/11(2006-11-01), 859-864 0093-7711 58:11<859 2006 58 251 https://doi.org/10.1007/s00251-006-0161-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-006-0161-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Meiqiang Medical College, Shandong University, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Cao Bangwei Department of Anti-infection, Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China aut NATIONALLICENCE 700 1- Zhang Hongkun Medical College, Shandong University, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Dai Yue Department of Blood Transfusion, Peking University First Hospital, Beijing, China aut NATIONALLICENCE 700 1- Liu Xiaolin Medical College, Shandong University, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Xu Changqing Qianfoshan Hospital, No. 66 Jing Shi Road, LiXia District, 250014, Jinan, Shandong Province, China aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/11(2006-11-01), 859-864 0093-7711 58:11<859 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer