caa a22 4500 467919062 CHVBK 20180406152911.0 cr unu---uuuuu 170328e20060101xx s 000 0 eng 10.1007/s00706-005-0403-y doi (NATIONALLICENCE)springer-10.1007/s00706-005-0403-y Symmetrical and Asymmetrical Bisphosphonate Esters. Synthesis, Selective Hydrolysis, and Isomerization [Elektronische Daten] [Wafaa M. Abdou, Neven A. Ganoub, Amin F. Fahmy, Abeer A. Shaddy] Summary.: Two simple and efficient one-pot procedures for the synthesis of a series of α-branched N-heterocycle-substituted methane-1,1-bisphosphonates are outlined. In the first method, the parent halosubstrates were reacted with cyanomethylphosphonate followed by reaction with dialkyl phosphonates to give asymmetrical or symmetrical bisphosphonates (BPs). In the second approach, the same halocompounds were reacted with tetraethyl methyl-1,1-bisphosphonate to give the requisite BPs. Partial and complete hydrolysis of the prepared BPs were also investigated. The products contain functional groups advantageous for further synthetic modification as structural units for coupling with the drug. Springer-Verlag/Wien, 2006 Keywords. Drug research nationallicence Carbanions nationallicence Methyl-1,1-bisphosphonates nationallicence Bone mineral affinity nationallicence Abdou Wafaa M. Department of Pesticide Chemistry, National Research Centre, Dokki, 12622, Cairo, Egypt aut Ganoub Neven A. Department of Pesticide Chemistry, National Research Centre, Dokki, 12622, Cairo, Egypt aut Fahmy Amin F. Department of Chemistry, Faculty of Science, Ain-Shams University, Cairo, Egypt aut Shaddy Abeer A. Department of Pesticide Chemistry, National Research Centre, Dokki, 12622, Cairo, Egypt aut Monatshefte für Chemie / Chemical Monthly Springer-Verlag 137/1(2006-01-01), 105-116 0026-9247 137:1<105 2006 137 706 https://doi.org/10.1007/s00706-005-0403-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00706-005-0403-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abdou Wafaa M. Department of Pesticide Chemistry, National Research Centre, Dokki, 12622, Cairo, Egypt aut NATIONALLICENCE 700 1- Ganoub Neven A. Department of Pesticide Chemistry, National Research Centre, Dokki, 12622, Cairo, Egypt aut NATIONALLICENCE 700 1- Fahmy Amin F. Department of Chemistry, Faculty of Science, Ain-Shams University, Cairo, Egypt aut NATIONALLICENCE 700 1- Shaddy Abeer A. Department of Pesticide Chemistry, National Research Centre, Dokki, 12622, Cairo, Egypt aut NATIONALLICENCE 773 0- Monatshefte für Chemie / Chemical Monthly Springer-Verlag 137/1(2006-01-01), 105-116 0026-9247 137:1<105 2006 137 706 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer