caa a22 4500 46791916X CHVBK 20180406152911.0 cr unu---uuuuu 170328e20060601xx s 000 0 eng 10.1007/s00706-006-0475-3 doi (NATIONALLICENCE)springer-10.1007/s00706-006-0475-3 Synthesis and Antimycobacterial Activity of New 2-Hydroxy- N -(3-oxo-1-thia-4-azaspiro[4.4]non-4-yl)/(3-oxo-1-thia-4-azaspiro[4.5]dec-4-yl)-2,2-diphenylacetamide Derivatives [Elektronische Daten] [Özlen Güzel, Eser İlhan, Aydın Salman] Summary.: 2-Hydroxy-2,2-diphenylacetohydrazide (2), cyclic ketones, and mercaptoalkanoic acids were converted into 2-hydroxy-N-(3-oxo-1-thia-4-azaspiro[4.4]non/[4.5]dec-4-yl)-2,2-diphenylacetamide derivatives (3, 4) in a one pot procedure. Compounds 3 and 4 were tested for in vitro antimycobacterial activity against M. tuberculosis H37Rv. The compounds were found to provide 0-86% inhibition of mycobacterial growth in the primary screen conducted at 6.25 μg/cm3. Springer-Verlag, 2006 Keywords. Spirothiazolidinones nationallicence Synthesis nationallicence Antimycobacterial activity nationallicence Güzel Özlen Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, Beyazıt, Istanbul, Turkey aut İlhan Eser Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, Beyazıt, Istanbul, Turkey aut Salman Aydın Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, Beyazıt, Istanbul, Turkey aut Monatshefte für Chemie / Chemical Monthly Springer-Verlag 137/6(2006-06-01), 795-801 0026-9247 137:6<795 2006 137 706 https://doi.org/10.1007/s00706-006-0475-3 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00706-006-0475-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Güzel Özlen Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, Beyazıt, Istanbul, Turkey aut NATIONALLICENCE 700 1- İlhan Eser Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, Beyazıt, Istanbul, Turkey aut NATIONALLICENCE 700 1- Salman Aydın Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, Beyazıt, Istanbul, Turkey aut NATIONALLICENCE 773 0- Monatshefte für Chemie / Chemical Monthly Springer-Verlag 137/6(2006-06-01), 795-801 0026-9247 137:6<795 2006 137 706 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer