caa a22 4500 467919372 CHVBK 20180406152912.0 cr unu---uuuuu 170328e20060901xx s 000 0 eng 10.1007/s00706-006-0516-y doi (NATIONALLICENCE)springer-10.1007/s00706-006-0516-y Spychala Jaroslaw Department of Chemistry, Adam Mickiewicz University, Poznan, Poland aut A Convenient Way to Methylated 2-Imidazolines. Syntheses of Fluorene and Triazine Cyclic Diamidines [Elektronische Daten] [Jaroslaw Spychala] Summary.: One N-methyl- and 4-substituted 2-imidazolines are described. Fluorene bisimidazolines were obtained in good yield (64-92%), starting from 2,7-dicyanofluorene and ammonium sulfide. In a two-step procedure the crude bisthioamide was reacted with excess diaminoalkane-ethanol (1:1 mixture) in an oil bath. This new procedure is superior over standard methods. For the sake of comparison, a new triazine bisimidazoline was prepared by direct conversion of the appropriate bisnitrile. Preliminary in vitro studies have shown an interesting anticancer activity of this compound (NSC 710607) against diverse human cancer types, including colon, CNS, melanoma, breast, non-small cell lung, and ovarian. Springer-Verlag, 2006 Keywords. Diamidines nationallicence Fluorenes nationallicence 2-Imidazolines nationallicence Triazines nationallicence Uracils nationallicence Monatshefte für Chemie / Chemical Monthly Springer-Verlag 137/9(2006-09-01), 1203-1210 0026-9247 137:9<1203 2006 137 706 https://doi.org/10.1007/s00706-006-0516-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00706-006-0516-y text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Spychala Jaroslaw Department of Chemistry, Adam Mickiewicz University, Poznan, Poland aut NATIONALLICENCE 773 0- Monatshefte für Chemie / Chemical Monthly Springer-Verlag 137/9(2006-09-01), 1203-1210 0026-9247 137:9<1203 2006 137 706 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer