caa a22 4500 467919658 CHVBK 20180406152913.0 cr unu---uuuuu 170328e20061201xx s 000 0 eng 10.1007/s00706-006-0546-5 doi (NATIONALLICENCE)springer-10.1007/s00706-006-0546-5 Synthesis and Antiproliferative Activity of Cyano and Amidino Substituted 2-Phenylbenzothiazoles [Elektronische Daten] [Livio Racanè, Vesna Tralić-Kulenović, Richard P. Kitson, Grace Karminski-Zamola] Summary.: Series of cyano, dicyano, amidino, and diamidino substituted 2-phenylbenzothiazoles were prepared. Mono- and dicyano substituted benzothiazoles were obtained by condensation of appropriate substituted benzaldehydes with 2-aminothiophenol or 4-amino-3-mercaptobenzonitrile. The appropriate amidines or diamidines were prepared by Pinner reaction. The compounds were tested against breast, prostate, and lung cancer cell lines in a 72 h cytotoxicity assay. Many of the compounds had at 10 μM activity equivalent to 2-(4-aminophenyl)benzothiazole, while four compounds had significantly better activity, particularly in the breast cancer model. Springer-Verlag, 2006 Keywords. Heterocycles nationallicence Benzothiazoles nationallicence Amidines nationallicence Antitumor agents nationallicence Structure-activity relationship nationallicence Racanè Livio Department of Applied Chemistry, Faculty of Textile Technology, University of Zagreb, Zagreb, Croatia aut Tralić-Kulenović Vesna Department of Applied Chemistry, Faculty of Textile Technology, University of Zagreb, Zagreb, Croatia aut Kitson Richard P. Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX, USA aut Karminski-Zamola Grace Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia aut Monatshefte für Chemie / Chemical Monthly Springer-Verlag 137/12(2006-12-01), 1571-1577 0026-9247 137:12<1571 2006 137 706 https://doi.org/10.1007/s00706-006-0546-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00706-006-0546-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Racanè Livio Department of Applied Chemistry, Faculty of Textile Technology, University of Zagreb, Zagreb, Croatia aut NATIONALLICENCE 700 1- Tralić-Kulenović Vesna Department of Applied Chemistry, Faculty of Textile Technology, University of Zagreb, Zagreb, Croatia aut NATIONALLICENCE 700 1- Kitson Richard P. Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX, USA aut NATIONALLICENCE 700 1- Karminski-Zamola Grace Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia aut NATIONALLICENCE 773 0- Monatshefte für Chemie / Chemical Monthly Springer-Verlag 137/12(2006-12-01), 1571-1577 0026-9247 137:12<1571 2006 137 706 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer