caa a22 4500 467919887 CHVBK 20180406152913.0 cr unu---uuuuu 170328e20061001xx s 000 0 eng 10.1007/s00706-006-0535-8 doi (NATIONALLICENCE)springer-10.1007/s00706-006-0535-8 Hydrazones and new Oximes of 4-Aminobicyclo[2.2.2]octanones and their Antiprotozoal Activities [Elektronische Daten] [Robert Weis, Marcel Kaiser, Reto Brun, Robert Saf, Werner Seebacher] Summary.: 4-Aminobicyclo[2.2.2]octan-2-ones and -ols showed activity against the causative organisms of East African sleeping sickness and Malaria tropica. Several imino derivatives of the ketones were more active. Now hydrazono analogues and 3-hydroximino derivatives of the ketones and alcohols were synthesized. The structures of the obtained isomers were elucidated by NMR spectroscopy. A single phenylhydrazone exhibited quite good antitrypanosomal activity in the range of already known imino analogues. Springer-Verlag, 2006 Keywords. Antiprotozoal activity nationallicence Imines nationallicence Isomers nationallicence Ketones nationallicence NMR spectroscopy nationallicence Weis Robert Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, Graz, Austria aut Kaiser Marcel Swiss Tropical Institute, Basel, Switzerland aut Brun Reto Swiss Tropical Institute, Basel, Switzerland aut Saf Robert Institute of Chemical Technology of Organic Materials, Erzherzog-Johann University, Graz, Austria aut Seebacher Werner Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, Graz, Austria aut Monatshefte für Chemie / Chemical Monthly Springer-Verlag 137/10(2006-10-01), 1365-1374 0026-9247 137:10<1365 2006 137 706 https://doi.org/10.1007/s00706-006-0535-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00706-006-0535-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Weis Robert Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Kaiser Marcel Swiss Tropical Institute, Basel, Switzerland aut NATIONALLICENCE 700 1- Brun Reto Swiss Tropical Institute, Basel, Switzerland aut NATIONALLICENCE 700 1- Saf Robert Institute of Chemical Technology of Organic Materials, Erzherzog-Johann University, Graz, Austria aut NATIONALLICENCE 700 1- Seebacher Werner Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, Graz, Austria aut NATIONALLICENCE 773 0- Monatshefte für Chemie / Chemical Monthly Springer-Verlag 137/10(2006-10-01), 1365-1374 0026-9247 137:10<1365 2006 137 706 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer