caa a22 4500 467919941 CHVBK 20180406152914.0 cr unu---uuuuu 170328e20060401xx s 000 0 eng 10.1007/s00706-006-0455-7 doi (NATIONALLICENCE)springer-10.1007/s00706-006-0455-7 Structural Requirements for the Antiprotozoal Activity of 4-Aminobicyclo[2.2.2]octan-2-ols [Elektronische Daten] [Werner Seebacher, Heinrich Berger, Marcel Kaiser, Reto Brun, Robert Saf, Robert Weis] Summary.: Several 4-aminobicyclo[2.2.2]octan-2-ones and -ols were synthesized using different pathways. The new compounds were investigated for their activity against Trypanosoma b. rhodesiense, the causative organism of East African sleeping sickness and Plasmodium falciparum the protozoan parasite which causes Malaria tropica. The results are compared to the activities of known compounds and the influence of the substitution of the bicyclo[2.2.2]octane skeleton on the biological activities is discussed. Springer-Verlag/Wien, 2006 Keywords. Antiplasmodial activity nationallicence Antitrypanosomal activity nationallicence Amino alcohols nationallicence Cyclizations nationallicence Structure-activity relationship nationallicence Seebacher Werner Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, A-8010, Graz, Austria aut Berger Heinrich Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, A-8010, Graz, Austria aut Kaiser Marcel Swiss Tropical Institute, CH-4002, Basel, Switzerland aut Brun Reto Swiss Tropical Institute, CH-4002, Basel, Switzerland aut Saf Robert Institute of Chemical Technology of Organic Materials, Erzherzog-Johann University, A-8010, Graz, Austria aut Weis Robert Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, A-8010, Graz, Austria aut Monatshefte für Chemie / Chemical Monthly Springer-Verlag 137/4(2006-04-01), 471-482 0026-9247 137:4<471 2006 137 706 https://doi.org/10.1007/s00706-006-0455-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00706-006-0455-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Seebacher Werner Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, A-8010, Graz, Austria aut NATIONALLICENCE 700 1- Berger Heinrich Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, A-8010, Graz, Austria aut NATIONALLICENCE 700 1- Kaiser Marcel Swiss Tropical Institute, CH-4002, Basel, Switzerland aut NATIONALLICENCE 700 1- Brun Reto Swiss Tropical Institute, CH-4002, Basel, Switzerland aut NATIONALLICENCE 700 1- Saf Robert Institute of Chemical Technology of Organic Materials, Erzherzog-Johann University, A-8010, Graz, Austria aut NATIONALLICENCE 700 1- Weis Robert Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, A-8010, Graz, Austria aut NATIONALLICENCE 773 0- Monatshefte für Chemie / Chemical Monthly Springer-Verlag 137/4(2006-04-01), 471-482 0026-9247 137:4<471 2006 137 706 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer