caa a22 4500 467921857 CHVBK 20180406152919.0 cr unu---uuuuu 170328e20060801xx s 000 0 ger 10.1007/s10309-006-0209-x doi (NATIONALLICENCE)springer-10.1007/s10309-006-0209-x Luef Gerhard Medizinische Universität Innsbruck, Universitätsklinik für Neurologie, Anichstraße 35, 6020, Innsbruck, Austria aut Pankreashormone und Leptin [Elektronische Daten] [Gerhard Luef] Pancreas hormones and leptin Abstract : A significant weight gain and increase in serum leptin levels in the course of antiepileptic treatment with valproic acid has been described in several clinical studies. With respect to the long treatment period in antiepileptic therapy, these side effects might increase insulin resistance and metabolic risk factors. The effect of valproate on insulin secretion in pancreatic islet cells was studied in in vitro experiments with islets from pancreases of multiorgan donors. It can be speculated that an increase in pancreatic insulin secretion under chronic valproate treatment enhances appetite and energy storage and is related to the observed weight gain. Changes in weight seem to affect the expression of PCOS in women with PCO, with a gain in weight being associated with a worsening of the symptoms of PCOS. Nonalcoholic fatty liver disease was defined recently as another symptom of insulin resistance in valproate treated patients. Leptin secreted from peripheral adipose tissue acts centrally within the mammalian hypothalamus to reduce appetite and promote a negative energy balance, as observed in Topiramate-treated patients. Elevated circulating leptin concentrations in obese humans fail to act in this way. Steinkopff-Verlag, 2006 Insulin nationallicence weight gain nationallicence epilepsy nationallicence antiepileptic drugs nationallicence valproate nationallicence Insulin nationallicence Gewichtszunahme nationallicence Epilepsie nationallicence Antiepileptika nationallicence Valproat nationallicence Zeitschrift für Epileptologie Steinkopff-Verlag 19/3(2006-08-01), 195-198 1617-6782 19:3<195 2006 19 10309 https://doi.org/10.1007/s10309-006-0209-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10309-006-0209-x text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Luef Gerhard Medizinische Universität Innsbruck, Universitätsklinik für Neurologie, Anichstraße 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 773 0- Zeitschrift für Epileptologie Steinkopff-Verlag 19/3(2006-08-01), 195-198 1617-6782 19:3<195 2006 19 10309 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer