caa a22 4500 467921903 CHVBK 20180406152919.0 cr unu---uuuuu 170328e20060801xx s 000 0 ger 10.1007/s10309-006-0213-1 doi (NATIONALLICENCE)springer-10.1007/s10309-006-0213-1 Epilepsie bei Männern [Elektronische Daten] Einflüsse der Erkrankung und ihrer Behandlung auf reproduktive endokrine Funktionen [Günter Krämer, Jürgen Bauer, Gerhard Luef] Epilepsy in men: The effect of the disease and its therapy on reproductive endocrine functions Abstract : In men with epilepsy, the disorder itself as well as its treatment may lead to hormonal changes. Focal seizures and especially temporal lobe epilepsy (TLE) have an impact on the hypothalamic- pituitary axis. Whereas seizures cause a shortlasting increase in serum levels of pituitary hormones, the impact of interictal focal epileptic activity is long lasting. In TLE a decrease of serum levels of free testosterone and the testosterone/luteotrophic hormone ratio is observed, indicating a testicular malfunction. Following successful epilepsy surgery in men with TLE, a significant increase in serum androgen levels is observed within a 12-month follow-up. The supprimation of epileptic acitivity by successful epilepsy surgery is followed by normalization of preoperatively decreased serum concentrations of androgens. In men with epilepsy an impairment of libido and erectile dysfunction are frequently reported, especially under therapy with enzyme inducing antiepileptic drugs (AEDs). Valproate may lead to a decrease of testicular volumes and increase of androgen serum levels. Carbamazepine as well as valproate may have negative effects on spermatogenesis. In comparison to carbamazepine, phenytoin and phenobarbital, which lead to increased serum levels of sexual hormone binding globulin and decreased levels of the biologically active free testosterone, oxcarbazepine offers advantages and in comparison to valproate other new AEDs like lamotrigine may be an alternative. Steinkopff-Verlag, 2006 Men with epilepsy nationallicence sexual hormones nationallicence enzyme inducing antiepileptic drugs nationallicence new antiepileptic drugs nationallicence Männer mit Epilepsie nationallicence Geschlechtshormone nationallicence enzyminduzierende Antiepileptika nationallicence neue Antiepileptika nationallicence Krämer Günter Schweizerisches Epilepsie-Zentrum, Bleulerstr. 60, 8008, Zürich, Switzerland aut Bauer Jürgen Universitäts-Klinik für Epileptologie, Bonn, Germany aut Luef Gerhard Department Neurologie, Medizinische Universitätsklinik, Innsbruck, Austria aut Zeitschrift für Epileptologie Steinkopff-Verlag 19/3(2006-08-01), 204-211 1617-6782 19:3<204 2006 19 10309 https://doi.org/10.1007/s10309-006-0213-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10309-006-0213-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Krämer Günter Schweizerisches Epilepsie-Zentrum, Bleulerstr. 60, 8008, Zürich, Switzerland aut NATIONALLICENCE 700 1- Bauer Jürgen Universitäts-Klinik für Epileptologie, Bonn, Germany aut NATIONALLICENCE 700 1- Luef Gerhard Department Neurologie, Medizinische Universitätsklinik, Innsbruck, Austria aut NATIONALLICENCE 773 0- Zeitschrift für Epileptologie Steinkopff-Verlag 19/3(2006-08-01), 204-211 1617-6782 19:3<204 2006 19 10309 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer