caa a22 4500 467922012 CHVBK 20180406152919.0 cr unu---uuuuu 170328e20061101xx s 000 0 ger 10.1007/s10309-006-0222-0 doi (NATIONALLICENCE)springer-10.1007/s10309-006-0222-0 Erfahrungen mit Generika bei Epilepsiepatienten [Elektronische Daten] Ergebnisse einer Internet-basierten Befragung in Deutschland, Österreich und der Schweiz * [Günter Krämer, Bernhard Steinhoff, Martha Feucht, Margarete Pfäfflin, Theodor May] Experiences with generic drugs in epilepsy patients. Results of an internet-based questionnaire study in Germany, Austria, and Switzerland Abstract : Whereas the use of generic drugs may be without problems in acute disorders, chronic diseases with the need of a stable medication may be different. This is especially true for epilepsy, where treatment with antiepileptic drugs (AEDs) is guided with surrogate markers like blood levels and where a single seizure recurrence may have severe consequences like loss of the driving license. We performed an internet-based questionnaire study in members of the German, Austrian and Swiss sections of the International League Against Epilepsy as well as members of the German Society for Neurology asking for their experience with generic preparations of antiepileptic drugs (G-AEDs). About 2800 e-mails were sent together with an accompanying letter signed by the presidents of the three league chapters on December 1, 2005. There was a link to a specially designed website for easy online response. We received more than 600 responses through January 31, 2006. About 80% of the physicians had experience with G-AEDs. About half of them reported problems with their usage, in decreasing order: additional telephone contacts or visits, hospital admissions, calls for emergency doctors or visits of emergency rooms, disturbances of the physician-patient relationship, sick certificates or injuries. In about half of the physicians these experiences had led to changes in their prescription behaviour (restrictions for substitution), in addition to increased patient counselling and blood level determinations of AEDs. The current criteria for approval of G-AEDs were considered as inappropriate by about 50%, and 90% considered it unacceptable that pharmacists have the possibility of substitution without consultation. In line with the results of a report from the US our study underlines the potential problems with the use of G-AEDs in antiepileptic therapy and justifies recommendations to avoid switching between different preparations (from brand-name drugs to generics as well as between generics or from generics to brand-name drugs) in successfully treated, especially seizure-free patients. Steinkopff-Verlag, 2006 Antiepileptic drugs nationallicence generics nationallicence substitution nationallicence recommendations nationallicence Antiepileptika nationallicence Generika nationallicence Substitution nationallicence Empfehlungen nationallicence Krämer Günter Schweizerisches Epilepsie-Zentrum, Bleulerstr. 60, 8008, Zürich, Switzerland aut Steinhoff Bernhard Epilepsie-Zentrum, Kehl-Kork, Deutschland aut Feucht Martha Universitätsklinik für Kinder- und Jugendheilkunde und Universitätsklinik für Neurophsychiatrie des Kindes- und Jugendalters, Medizinische Universität Wien, Wien, Österreich aut Pfäfflin Margarete Gesellschaft für Epilepsieforschung, Koordinierungszentrum für Studien in der Epileptologie, Bielefeld, Deutschland aut May Theodor Gesellschaft für Epilepsieforschung, Koordinierungszentrum für Studien in der Epileptologie, Bielefeld, Deutschland aut Zeitschrift für Epileptologie Steinkopff-Verlag 19/4(2006-11-01), 265-275 1617-6782 19:4<265 2006 19 10309 https://doi.org/10.1007/s10309-006-0222-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10309-006-0222-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Krämer Günter Schweizerisches Epilepsie-Zentrum, Bleulerstr. 60, 8008, Zürich, Switzerland aut NATIONALLICENCE 700 1- Steinhoff Bernhard Epilepsie-Zentrum, Kehl-Kork, Deutschland aut NATIONALLICENCE 700 1- Feucht Martha Universitätsklinik für Kinder- und Jugendheilkunde und Universitätsklinik für Neurophsychiatrie des Kindes- und Jugendalters, Medizinische Universität Wien, Wien, Österreich aut NATIONALLICENCE 700 1- Pfäfflin Margarete Gesellschaft für Epilepsieforschung, Koordinierungszentrum für Studien in der Epileptologie, Bielefeld, Deutschland aut NATIONALLICENCE 700 1- May Theodor Gesellschaft für Epilepsieforschung, Koordinierungszentrum für Studien in der Epileptologie, Bielefeld, Deutschland aut NATIONALLICENCE 773 0- Zeitschrift für Epileptologie Steinkopff-Verlag 19/4(2006-11-01), 265-275 1617-6782 19:4<265 2006 19 10309 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer