caa a22 4500 467922144 CHVBK 20180406152919.0 cr unu---uuuuu 170328e20060501xx s 000 0 ger 10.1007/s10309-006-0194-0 doi (NATIONALLICENCE)springer-10.1007/s10309-006-0194-0 Störung der kardialen sympathischen Innervation als Ursache für SUDEP? [Elektronische Daten] [Frank Kerling, Matthias Dütsch, Torsten Kuwert, Hermann Stefan] Dysfunction of the cardiac sympathetic innervation—an explanation for SUDEP? Sudden unexpected death in epilepsy (SUDEP) concerns 7-17% of the mortality in epilepsy patients. The pathophysiological mechanism is not clearly defined. Autopsy studies show lung as well as brain oedema or myocardial ischemia. Autonomic disregulations are also discussed as a reason for SUDEP. During 10 years of presurgical video-EEG monitoring at the epilepsy center in Erlangen 663 patients were studied. Four patients showed in 8 out of 36 seizures asystoles with a duration up to 25 seconds. Cardiologic tests (Holter ECG, echocardiography etc.) and an examination of the sympathetic cardiac innervation (MIBG-SPECT) were performed. Whereas the cardiological measurements were without pathological findings, the MIBG-SPECT revealed diminished tracer uptake in the two patients with longer asystoles. This lack of sympathetic cardiac activity may lead to an insufficient counter regulation of the sympathicus, when there is an increased ictal vagotonus and might be a reason for SUDEP. Steinkopff-Verlag, 2006 Asystoles nationallicence temporal lobe epilepsy nationallicence MIBG-SPECT nationallicence SUDEP nationallicence sympathicus nationallicence Asystolie nationallicence Temporallappenepilepsie nationallicence MIBG-SPECT nationallicence Sympathikus nationallicence SUDEP nationallicence Kerling Frank Epilepsiezentrum des Universitätsklinikums Erlangen (Leiter: Prof. Dr. med. Hermann Stefan), Schwabachanlage 6, 91054, Erlangen, Germany aut Dütsch Matthias Epilepsiezentrum des Universitätsklinikums Erlangen (Leiter: Prof. Dr. med. Hermann Stefan), Schwabachanlage 6, 91054, Erlangen, Germany aut Kuwert Torsten Nuklearmedizinische Klinik des Universitätsklinikums Erlangen, Direktor: Prof. Dr. med. Torsten Kuwert), Krankenhausstr. 12, 91054, Erlangen, Germany aut Stefan Hermann Epilepsiezentrum des Universitätsklinikums Erlangen (Leiter: Prof. Dr. med. Hermann Stefan), Schwabachanlage 6, 91054, Erlangen, Germany aut Zeitschrift für Epileptologie Steinkopff-Verlag 19/2(2006-05-01), 84-88 1617-6782 19:2<84 2006 19 10309 https://doi.org/10.1007/s10309-006-0194-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10309-006-0194-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kerling Frank Epilepsiezentrum des Universitätsklinikums Erlangen (Leiter: Prof. Dr. med. Hermann Stefan), Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Dütsch Matthias Epilepsiezentrum des Universitätsklinikums Erlangen (Leiter: Prof. Dr. med. Hermann Stefan), Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Kuwert Torsten Nuklearmedizinische Klinik des Universitätsklinikums Erlangen, Direktor: Prof. Dr. med. Torsten Kuwert), Krankenhausstr. 12, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Stefan Hermann Epilepsiezentrum des Universitätsklinikums Erlangen (Leiter: Prof. Dr. med. Hermann Stefan), Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 773 0- Zeitschrift für Epileptologie Steinkopff-Verlag 19/2(2006-05-01), 84-88 1617-6782 19:2<84 2006 19 10309 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer