caa a22 4500 467922217 CHVBK 20180406152920.0 cr unu---uuuuu 170328e20060501xx s 000 0 ger 10.1007/s10309-006-0196-y doi (NATIONALLICENCE)springer-10.1007/s10309-006-0196-y Sudden unexpected death in epilepsy (SUDEP) [Elektronische Daten] Pathophysiologische Überlegungen [Matthias Dütsch, Frank Kerling, Hermann Stefan] Sudden unexpected death in epilepsy (SUDEP)—pathophysiological considerations By definition, the diagnosis "SUDEP” means that the exact cause of death cannot be determined. The death is "without (obvious) explanation”. Still, there are several hints to the underlying pathophysiological mechanisms of SUDEP. Epidemiologic studies have identified risk factors for the occurrence of SUDEP. These risk factors comprise, e. g., male sex, increased seizure frequency, subtherapeutic drug levels, frequently changing combinations of antiepileptic drugs. Autopsies of SUDEP victims demonstrated subendocardial myocardial ischemia or cerebral as well as pulmonary edema. The occurrence of SUDEP might be related to dysfunction of the central autonomic nervous system. Studies on epilepsy patients as well as animal experiments support the hypothesis that (inter)ictal epileptic activity leads to excessive sympathetic stimulation resulting in, e. g., neurogenic pulmonary edema, myocardial ischemia or cardiac arrhythmia. Further studies investigating the pathophysiology of SUDEP are necessary to establish reasonable preventive measures that might contribute to a reduction of the 2- to 5-fold increased mortality rates in epilepsy patients. Steinkopff-Verlag, 2006 SUDEP nationallicence pathophysiology nationallicence autonomic nervous system nationallicence mortality nationallicence SUDEP nationallicence Pathophysiologie nationallicence autonomes Nervensystem nationallicence Mortalität nationallicence Dütsch Matthias Epilepsiezentrum Erlangen (ZEE), Schwabachanlage 6, 91054, Erlangen aut Kerling Frank Epilepsiezentrum Erlangen (ZEE) (Leiter: Prof. Dr. H. Stefan), Erlangen aut Stefan Hermann Epilepsiezentrum Erlangen (ZEE) (Leiter: Prof. Dr. H. Stefan), Erlangen aut Zeitschrift für Epileptologie Steinkopff-Verlag 19/2(2006-05-01), 71-76 1617-6782 19:2<71 2006 19 10309 https://doi.org/10.1007/s10309-006-0196-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10309-006-0196-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dütsch Matthias Epilepsiezentrum Erlangen (ZEE), Schwabachanlage 6, 91054, Erlangen aut NATIONALLICENCE 700 1- Kerling Frank Epilepsiezentrum Erlangen (ZEE) (Leiter: Prof. Dr. H. Stefan), Erlangen aut NATIONALLICENCE 700 1- Stefan Hermann Epilepsiezentrum Erlangen (ZEE) (Leiter: Prof. Dr. H. Stefan), Erlangen aut NATIONALLICENCE 773 0- Zeitschrift für Epileptologie Steinkopff-Verlag 19/2(2006-05-01), 71-76 1617-6782 19:2<71 2006 19 10309 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer