caa a22 4500 467928169 CHVBK 20180406152935.0 cr unu---uuuuu 170328e20060901xx s 000 0 eng 10.1007/s10266-006-0064-2 doi (NATIONALLICENCE)springer-10.1007/s10266-006-0064-2 Kurabuchi Shingo Department of Histology, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, 102-8159, Tokyo, Japan aut Repeated androgen and thyroid hormone injection modulates the morphology of hormone-responsive duct cells in the mouse parotid gland [Elektronische Daten] [Shingo Kurabuchi] When the parotid glands of normal male and female ICR mice (12 weeks of age) were examined under a light microscope, no granular cells were seen in the duct system. However, transmission electron microscopy revealed that, in both sexes, many striated duct cells contained a few electron-dense secretory granules in their subluminal cytoplasm and had formed so-called granular striated tubules (GSTs) in some of the striated duct segments. These secretory granules were not large enough to be visible with a light microscope. Fully fledged granular cells, containing large secretory granules visible with a light microscope, could be induced in the GST segments of the glands of males by injection with 5α-dihydrotestosterone (DHT), triiodothyronine (T3), and dexamethasone (Dex), given alone or in combination every other day for 2 weeks. Dex alone showed no effect on the GSTs in this study. Both DHT and T3, either individually or with Dex, were moderately effective, inducing a few scattered fully fledged granular cells. A stronger effect was detected after concomitant injection of DHT and T3, with or without Dex, with more abundant fully developed granular cells appearing in the GST segments. Electron microscopy revealed that these granular cells had abundant large secretory granules in their apical two-thirds, a basal nucleus, and modest basal infoldings. By contrast, the effect of the same hormones was very weak in the glands of females, and even the concomitant injection of DHT and T3, with or without Dex, rarely induced fully fledged granular cells. These results indicate a close similarity between the ductal systems of the major salivary glands of the mouse, in terms of some of the striated duct segments containing secretory granules, being under the same multihormonal regulation, and being sexually dimorphic. The Society of The Nippon Dental University, 2006 Granular striated tubule (GST) nationallicence Secretory granules nationallicence Parotid gland nationallicence Electron microscopy nationallicence Hormonal regulation nationallicence Odontology Springer-Verlag 94/1(2006-09-01), 29-37 1618-1247 94:1<29 2006 94 10266 https://doi.org/10.1007/s10266-006-0064-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10266-006-0064-2 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Kurabuchi Shingo Department of Histology, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, 102-8159, Tokyo, Japan aut NATIONALLICENCE 773 0- Odontology Springer-Verlag 94/1(2006-09-01), 29-37 1618-1247 94:1<29 2006 94 10266 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer