caa a22 4500 467932581 CHVBK 20180406152947.0 cr unu---uuuuu 170328e20060201xx s 000 0 eng 10.1007/s10545-006-0106-5 doi (NATIONALLICENCE)springer-10.1007/s10545-006-0106-5 Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: An overview [Elektronische Daten] [R. Castro, I. Rivera, H. Blom, C. Jakobs, I. de Almeida] Summary: Hyperhomocysteinaemia has been regarded as a new modifiable risk factor for atherosclerosis and vascular disease. Homocysteine is a branch-point intermediate of methionine metabolism, which can be further metabolised via two alternative pathways: degraded irreversibly through the transsulphuration pathway or remethylated to methionine by the remethylation pathway. Both pathways are B-vitamin-dependent. Plasma homocysteine concentrations are determined by nongenetic and genetic factors. The metabolism of homocysteine, the role of B vitamins and the contribution of nongenetic and genetic determinants of homocysteine concentrations are reviewed. The mechanisms whereby homocysteine causes endothelial damage and vascular disease are not fully understood. Recently, a link has been postulated between homocysteine, or its intermediates, and an alterated DNA methylation pattern. The involvement of epigenetic mechanisms in the context of homocysteine and atherosclerosis, due to inhibition of transmethylation reactions, is briefly overviewed. SSIEM and Springer, 2006 Castro R. Centro de Patogénese Molecular, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal aut Rivera I. Centro de Patogénese Molecular, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal aut Blom H. Department of Paediatrics, University Medical Center, St. Radboud, Nijmegen, The Netherlands aut Jakobs C. Metabolic Unit, Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, The Netherlands aut de Almeida I. Centro de Patogénese Molecular, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal aut Journal of Inherited Metabolic Disease Kluwer Academic Publishers 29/1(2006-02-01), 3-20 0141-8955 29:1<3 2006 29 10545 https://doi.org/10.1007/s10545-006-0106-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10545-006-0106-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Castro R. Centro de Patogénese Molecular, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal aut NATIONALLICENCE 700 1- Rivera I. Centro de Patogénese Molecular, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal aut NATIONALLICENCE 700 1- Blom H. Department of Paediatrics, University Medical Center, St. Radboud, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Jakobs C. Metabolic Unit, Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- de Almeida I. Centro de Patogénese Molecular, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal aut NATIONALLICENCE 773 0- Journal of Inherited Metabolic Disease Kluwer Academic Publishers 29/1(2006-02-01), 3-20 0141-8955 29:1<3 2006 29 10545 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer