caa a22 4500 467932697 CHVBK 20180406152947.0 cr unu---uuuuu 170328e20060201xx s 000 0 eng 10.1007/s10545-006-0154-x doi (NATIONALLICENCE)springer-10.1007/s10545-006-0154-x Psychological complications of patients with Gaucher disease [Elektronische Daten] [W. Packman, T. Crosbie, A. Riesner, C. Fairley, S. Packman] Summary: The Minnesota Multiphasic Personality Inventory (MMPI-2) is commonly used in chronic illness and chronic pain populations to assess psychological functioning. We report the results of the first study employing the MMPI-2 to assess psychological aspects of patients with Gaucher disease, type I (GD) is an inborn error of metabolism with unique features as a chronic illness: the disorder often presents with mild symptoms, and is frequently diagnosed in later childhood or adulthood; the treatment is highly efficacious, but, that same treatment is intrusive and expensive and requires that patients restructure their work and personal schedules. In this study, 28 patients with GD completed the MMPI-2 and a background questionnaire. GD patients scored significantly higher than the MMPI-2 normative sample on MMPI-2 scales of Validity (K), Hypochondriasis (Hs), Depression (D), Hysteria (Hy), Psychasthenia (Pt) and Schizophrenia (Sc). Individuals with elevated scores on the Hs, D and Hy scales tend to have somatic concerns and depressed mood. Under stress, they are likely to report physical symptoms. Elevated Pt and Sc scales suggest psychological turmoil and, possibly feelings of isolation. An elevated K scale indicates a tendency for individuals to deny psychopathology. The length of time the patient with GD had been on enzyme replacement therapy was not significantly related to any of the 13 MMPI-2 scales. Cohorts of patients with chronic heart disease (CRHD) and cohorts of patients with chronic pain were utilized as comparative populations in this investigation. The elevated scores of the GD patients on MMPI-2 scales Hs, D and Hy were similar to those of the CRHD population. The chronic pain patients also showed elevations on MMPI-2 scales Hs, D and Hy, which were elevated in the GD patients; the elevations in the chronic pain patients were higher than those shown by the GD patients. We conclude that patients with GD exhibit moderate to severe psychological complications, similar to patients with other long-term chronic illnesses. SSIEM and Springer, 2006 Packman W. Pacific Graduate School of Psychology, 935 E. Meadow Drive, 94303, Palo Alto, CA, USA aut Crosbie T. Pacific Graduate School of Psychology, 935 E. Meadow Drive, 94303, Palo Alto, CA, USA aut Riesner A. University of California, San Francisco, California, USA aut Fairley C. University of California, San Francisco, California, USA aut Packman S. University of California, San Francisco, California, USA aut Journal of Inherited Metabolic Disease Kluwer Academic Publishers 29/1(2006-02-01), 99-105 0141-8955 29:1<99 2006 29 10545 https://doi.org/10.1007/s10545-006-0154-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10545-006-0154-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Packman W. Pacific Graduate School of Psychology, 935 E. Meadow Drive, 94303, Palo Alto, CA, USA aut NATIONALLICENCE 700 1- Crosbie T. Pacific Graduate School of Psychology, 935 E. Meadow Drive, 94303, Palo Alto, CA, USA aut NATIONALLICENCE 700 1- Riesner A. University of California, San Francisco, California, USA aut NATIONALLICENCE 700 1- Fairley C. University of California, San Francisco, California, USA aut NATIONALLICENCE 700 1- Packman S. University of California, San Francisco, California, USA aut NATIONALLICENCE 773 0- Journal of Inherited Metabolic Disease Kluwer Academic Publishers 29/1(2006-02-01), 99-105 0141-8955 29:1<99 2006 29 10545 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer