caa a22 4500 467933162 CHVBK 20180406152949.0 cr unu---uuuuu 170328e20060401xx s 000 0 eng 10.1007/s10545-006-0320-1 doi (NATIONALLICENCE)springer-10.1007/s10545-006-0320-1 Anaplerotic molecules: Current and future [Elektronische Daten] [Henri Brunengraber, Charles Roe] Summary: This review presents the concepts of anaplerosis and cataplerosis in relation to the regulation of citric acid cycle operation. Anaplerosis is the re-filling of the catalytic intermediates of the cycle that carry acetyl-CoA as it is oxidized. The main anaplerotic substrates are pyruvate, glutamine/glutamate and precursors of propionyl-CoA (odd-chain fatty acids, specific amino acids, C5-ketone bodies). Cataplerosis balances anaplerosis by removing excess intermediates from the citric acid cycle. The properties of the main anaplerotic substrates are reviewed from the point of view of potential clinical applications to the treatment of some inherited and acquired conditions. SSIEM and Springer, 2006 Brunengraber Henri Department of Nutrition, Case Western Reserve University, 10900 Euclid Avenue, 44106-4906, Cleveland, OH, USA aut Roe Charles Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Texas, USA aut Journal of Inherited Metabolic Disease Kluwer Academic Publishers 29/2-3(2006-04-01), 327-331 0141-8955 29:2-3<327 2006 29 10545 https://doi.org/10.1007/s10545-006-0320-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10545-006-0320-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brunengraber Henri Department of Nutrition, Case Western Reserve University, 10900 Euclid Avenue, 44106-4906, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Roe Charles Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Texas, USA aut NATIONALLICENCE 773 0- Journal of Inherited Metabolic Disease Kluwer Academic Publishers 29/2-3(2006-04-01), 327-331 0141-8955 29:2-3<327 2006 29 10545 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer