caa a22 4500 467934592 CHVBK 20180406152953.0 cr unu---uuuuu 170328e20060201xx s 000 0 eng 10.1007/s00408-005-2563-2 doi (NATIONALLICENCE)springer-10.1007/s00408-005-2563-2 Sleep-Disordered Breathing in Nondialyzed Patients with Chronic Renal Failure [Elektronische Daten] [Nikolaos Markou, Maria Kanakaki, Pavlos Myrianthefs, Dimitrios Hadjiyanakos, Dimosthenis Vlassopoulos, Anastasios Damianos, Konstantinos Siamopoulos, Miltiadis Vasiliou, Stavros Konstantopoulos] The prevalence and significance of sleep-disordered breathing (SDB) in dialysis-independent chronic renal failure (CRF) remains unknown. We studied the presence of SDB in nondialyzed CRF patients. Diagnostic polysomnography was performed in consecutive stable nondialyzed CRF patients. Inclusion criteria were age ≤70 years, absence of systolic dysfunction or history of pulmonary edema, FEV1 > 70% pr, absence of neurologic disease or hypothyroidism, and calculated creatinine clearance <40 ml/min. Thirty-five patients (19 male, 16 female) were studied. An apnea-hypopnea index (AHI) ≥5/h was present in 54.3% (almost exclusively obstructive events). AHI correlated with urea (r = 0.35, p = 0.037), age (r = 0.379, p = 0.025), and body mass index (BMI) (r = 0.351, p = 0.038), but not with creatinine clearance. AHI or SDB were unrelated to gender. In nondiabetics (n = 25), AHI correlated with urea (r = 0.608, p = 0.001) and creatinine clearance (r = −0.50, p = 0.012). Nondiabetics with severe CRF (calculated GFR < 15 ml/min/1.73 m2) had a significantly higher AHI compared with less severe CRF. Restless legs syndrome (RLS) was present in 37.1% and periodic limb movements in 28.6%. Daytime sleepiness was not associated with respiratory events, but was more common in patients with RLS. The prevalence of SDB and RLS is high in dialysis-independent CRF. SDB weakly correlates with indices of kidney function and this association becomes stronger in nondiabetics. Springer Science+Business Media, Inc., 2006 Chronic renal failure nationallicence Dialysis nationallicence Sleep-disordered breathing nationallicence Restless legs syndrome nationallicence Periodic limb movements nationallicence Markou Nikolaos Department of Pulmonary Medicine, "A Fleming” General Hospital, 2 Pigis St., 15126, Mellisia, Athens, Greece aut Kanakaki Maria Department of Pulmonary Medicine, "A Fleming” General Hospital, 2 Pigis St., 15126, Mellisia, Athens, Greece aut Myrianthefs Pavlos Athens School of Nursing, ICU at KAT Hospital, 2 Nikis St., 14561, Kifisia, Athens, Greece aut Hadjiyanakos Dimitrios Department of Nephrology, "A Fleming” General Hospital, 14 25th March St., 15126, Mellisia, Athens, Greece aut Vlassopoulos Dimosthenis Department of Nephrology, "A Fleming” General Hospital, 14 25th March St., 15126, Mellisia, Athens, Greece aut Damianos Anastasios Department of Pulmonary Medicine, "A Fleming” General Hospital, 2 Pigis St., 15126, Mellisia, Athens, Greece aut Siamopoulos Konstantinos Department of Nephrology, University Hospital of Ioannina, P.O. Box 1186, 45110, Ioannina, Greece aut Vasiliou Miltiadis Department of Pulmonary Medicine, University Hospital of Ioannina, P.O. Box 1186, 45110, Ioannina, Greece aut Konstantopoulos Stavros Department of Pulmonary Medicine, University Hospital of Ioannina, P.O. Box 1186, 45110, Ioannina, Greece aut Lung Springer-Verlag; www.springer-ny.com 184/1(2006-02-01), 43-49 0341-2040 184:1<43 2006 184 408 https://doi.org/10.1007/s00408-005-2563-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2563-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Markou Nikolaos Department of Pulmonary Medicine, "A Fleming” General Hospital, 2 Pigis St., 15126, Mellisia, Athens, Greece aut NATIONALLICENCE 700 1- Kanakaki Maria Department of Pulmonary Medicine, "A Fleming” General Hospital, 2 Pigis St., 15126, Mellisia, Athens, Greece aut NATIONALLICENCE 700 1- Myrianthefs Pavlos Athens School of Nursing, ICU at KAT Hospital, 2 Nikis St., 14561, Kifisia, Athens, Greece aut NATIONALLICENCE 700 1- Hadjiyanakos Dimitrios Department of Nephrology, "A Fleming” General Hospital, 14 25th March St., 15126, Mellisia, Athens, Greece aut NATIONALLICENCE 700 1- Vlassopoulos Dimosthenis Department of Nephrology, "A Fleming” General Hospital, 14 25th March St., 15126, Mellisia, Athens, Greece aut NATIONALLICENCE 700 1- Damianos Anastasios Department of Pulmonary Medicine, "A Fleming” General Hospital, 2 Pigis St., 15126, Mellisia, Athens, Greece aut NATIONALLICENCE 700 1- Siamopoulos Konstantinos Department of Nephrology, University Hospital of Ioannina, P.O. Box 1186, 45110, Ioannina, Greece aut NATIONALLICENCE 700 1- Vasiliou Miltiadis Department of Pulmonary Medicine, University Hospital of Ioannina, P.O. Box 1186, 45110, Ioannina, Greece aut NATIONALLICENCE 700 1- Konstantopoulos Stavros Department of Pulmonary Medicine, University Hospital of Ioannina, P.O. Box 1186, 45110, Ioannina, Greece aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/1(2006-02-01), 43-49 0341-2040 184:1<43 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer