caa a22 4500 467934606 CHVBK 20180406152953.0 cr unu---uuuuu 170328e20060201xx s 000 0 eng 10.1007/s00408-005-2550-7 doi (NATIONALLICENCE)springer-10.1007/s00408-005-2550-7 Inhaled Nitric Oxide Improves Pulmonary Functions Following Massive Pulmonary Embolism: A Report of Four Patients and Review of the Literature [Elektronische Daten] [Oded Szold, Wisam Khoury, Philippe Biderman, Joseph Klausner, Pinchas Halpern, Avi Weinbroum] Acute pulmonary embolism increases pulmonary vascular resistance and may lead to acute right ventricular failure and cardiocirculatory collapse and respiratory failure, possibly resulting in substantial morbidity and mortality. Inhaled nitric oxide (NO) dilates pulmonary blood vessels and has been used to reduce pulmonary vascular resistance in patients with chronic thromboembolic pulmonary hypertension and acute respiratory distress syndrome. This case series describes our experience with inhaled NO administered to four patients suffering from acute massive pulmonary embolism following abdominal surgery. The four described patients recovering from small bowel resection, pancreatoduodenectomy, hemipelvectomy, or recent gastrointestinal bleeding had severe respiratory and hemodynamic deterioration due to pulmonary embolism. Each received inhaled NO (20-25 ppm) via the inspiratory side of the breathing circuit of the ventilator. Pulmonary and systemic blood pressures, heart rate, and lung gas exchange improved in all the patients within minutes after the initiation of NO administration. Inhaled NO may be useful in treating acute massive pulmonary embolism. This potential application warrants further investigation. Springer Science+Business Media, Inc., 2006 Pulmonary embolism nationallicence Pulmonary hypertension nationallicence Nitric oxide nationallicence Szold Oded Surgical Intensive Care Unit, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut Khoury Wisam Surgical Intensive Care Unit, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut Biderman Philippe Surgical Intensive Care Unit, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut Klausner Joseph Department of Surgery "B”, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut Halpern Pinchas Emergency Medicine, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut Weinbroum Avi Post-Anesthesia Care Unit, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut Lung Springer-Verlag; www.springer-ny.com 184/1(2006-02-01), 1-5 0341-2040 184:1<1 2006 184 408 https://doi.org/10.1007/s00408-005-2550-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2550-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Szold Oded Surgical Intensive Care Unit, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Khoury Wisam Surgical Intensive Care Unit, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Biderman Philippe Surgical Intensive Care Unit, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Klausner Joseph Department of Surgery "B”, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Halpern Pinchas Emergency Medicine, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Weinbroum Avi Post-Anesthesia Care Unit, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/1(2006-02-01), 1-5 0341-2040 184:1<1 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer