caa a22 4500 467934622 CHVBK 20180406152953.0 cr unu---uuuuu 170328e20060201xx s 000 0 eng 10.1007/s00408-005-2556-1 doi (NATIONALLICENCE)springer-10.1007/s00408-005-2556-1 Elevated Carbon Dioxide Tension as a Predictor of Subsequent Adverse Events in Infants with Bronchopulmonary Dysplasia [Elektronische Daten] [Thomas Kovesi, Adel Abdurahman, Marc Blayney] Infants with bronchopulmonary dysplasia (BPD) are at risk for numerous complications following discharge from the Neonatal Intensive Care Unit (NICU). Few studies have evaluated risk factors for adverse events (AE). This retrospective study provided an initial evaluation of the use of capillary carbon dioxide (PCO2) tension as a predictor of infants with BPD at increased risk for AE. PCO2 was compared in patients who suffered, or avoided, severe AE, defined as pulmonary hypertension, death, or subsequent reintubation or tracheostomy for respiratory illness. One hundred twelve consecutive patients followed at the BPD clinic were evaluated, and data from 104 subjects were suitable for analysis. Mean PCO2, obtained shortly before or after discharge from NICU, was 47.2 mmHg (range, 31-83). PCO2 was significantly higher in patients who required reintubation and ventilation (54.7 vs. 46.7, p < 0.04). No cutoff value of PCO2 clearly distinguished patients with subsequent AE. PCO2 was not significantly higher in the group of patients who had a severe AE than in the group of patients who did not have a severe AE, but logistic regression showed a significant association between PCO2 and risk of both severe AE (p = 0.018), and readmission to hospital (p = 0.038). An elevated PCO2 is associated with an increased risk of AE, including reintubation, and readmission to hospital, in infants with BPD. Patients with an elevated discharge PCO2 may require closer monitoring during followup. Prospective studies will be needed to confirm these observations. Springer Science+Business Media, Inc., 2006 Bronchopulmonary dysplasia nationallicence Carbon dioxide nationallicence Hypercapnia nationallicence Respiratory insufficiency nationallicence Hypertension, pulmonary nationallicence Kovesi Thomas Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa aut Abdurahman Adel University of Ottawa, School of Medicine, Ottawa, Canada aut Blayney Marc Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa aut Lung Springer-Verlag; www.springer-ny.com 184/1(2006-02-01), 7-13 0341-2040 184:1<7 2006 184 408 https://doi.org/10.1007/s00408-005-2556-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2556-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kovesi Thomas Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa aut NATIONALLICENCE 700 1- Abdurahman Adel University of Ottawa, School of Medicine, Ottawa, Canada aut NATIONALLICENCE 700 1- Blayney Marc Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/1(2006-02-01), 7-13 0341-2040 184:1<7 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer