caa a22 4500 467934649 CHVBK 20180406152953.0 cr unu---uuuuu 170328e20061201xx s 000 0 eng 10.1007/s00408-006-0006-3 doi (NATIONALLICENCE)springer-10.1007/s00408-006-0006-3 Acute Effect of Cigarette Smoke and Nicotine on Airway Blood Flow and Airflow in Healthy Smokers [Elektronische Daten] [Kanwaldeep Randhawa, Eliana Mendes, Adam Wanner] Cigarette smoke contains irritants and vasoactive substances. We wanted to determine the effect of smoking a cigarette and of nasally or orally inhaled nicotine on airway blood flow (Qaw) and airflow in smokers. In ten healthy current smokers, Qaw, FEV1, and FEF25-75 were measured before and at 5, 30, and 180 min after smoking a cigarette. The effects of systemic nicotine using a nicotine nasal spray and local nicotine using a nicotine inhaler were also studied. Mean (± SE) Qaw increased by 81% ± 16% (p = 0.03) 5 min after smoking a cigarette and was no longer different from baseline at 30 and 180 min. Nicotine nasal spray and nicotine oral inhaler had no effect on Qaw. FEV1 and FEF25-75 remained unchanged after smoking a cigarette and after local or systemic nicotine administration. Smoking a cigarette is followed by a transient increase in airway blood flow but no changes in airflow. Nicotine, at the rate and dose provided by the nasal spray (systemic action) and oral inhaler (local and systemic action), does not appear to be involved in the Qaw change, suggesting a pharmacologic or nonspecific irritant effect of other cigarette smoke constituents. Springer Science+Business Media, Inc., 2006 Airway blood flow nationallicence Cigarette smoking nationallicence Spirometry and nicotine nationallicence Qaw : airway blood flow nationallicence FEV1 : forced 1-s expiratory volume nationallicence FVC : forced vital capacity nationallicence FEF25-75 : forced midexpiratory flow nationallicence DME : dimethylether nationallicence NO : nitric oxide nationallicence Randhawa Kanwaldeep Division of Pulmonary and Critical Care Medicine, Cedars Sinai Medical Center, 8700 Beverly Blvd., Room 6732, 90048, Los Angeles, California, USA aut Mendes Eliana Division of Pulmonary and Critical Care Medicine, Department of Medicine, Miller School of Medicine, University of Miami, 33124, Coral Gables, Florida, USA aut Wanner Adam Division of Pulmonary and Critical Care Medicine, Department of Medicine, Miller School of Medicine, University of Miami, 33124, Coral Gables, Florida, USA aut Lung Springer-Verlag; www.springer-ny.com 184/6(2006-12-01), 363-368 0341-2040 184:6<363 2006 184 408 https://doi.org/10.1007/s00408-006-0006-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-006-0006-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Randhawa Kanwaldeep Division of Pulmonary and Critical Care Medicine, Cedars Sinai Medical Center, 8700 Beverly Blvd., Room 6732, 90048, Los Angeles, California, USA aut NATIONALLICENCE 700 1- Mendes Eliana Division of Pulmonary and Critical Care Medicine, Department of Medicine, Miller School of Medicine, University of Miami, 33124, Coral Gables, Florida, USA aut NATIONALLICENCE 700 1- Wanner Adam Division of Pulmonary and Critical Care Medicine, Department of Medicine, Miller School of Medicine, University of Miami, 33124, Coral Gables, Florida, USA aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/6(2006-12-01), 363-368 0341-2040 184:6<363 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer