caa a22 4500 467934665 CHVBK 20180406152953.0 cr unu---uuuuu 170328e20061201xx s 000 0 eng 10.1007/s00408-006-0011-6 doi (NATIONALLICENCE)springer-10.1007/s00408-006-0011-6 Salmeterol Improves Pulmonary Function in Persons with Tetraplegia [Elektronische Daten] [David Grimm, Gregory Schilero, Ann Spungen, William Bauman, Marvin Lesser] β2-Adrenergic agonists are known to improve muscle strength because of anabolic properties. The purpose of this study was to determine if long-term administration of a long-acting β2-adrenergic agonist to subjects with tetraplegia is associated with improvement in pulmonary function parameters and maximal static inspiratory and expiratory mouth pressures (MIP and MEP, respectively), measures of respiratory muscle strength. The study was a randomized, prospective, double-blind, placebo-controlled, crossover trial and conducted at the James J. Peters Veterans Affairs Medical Center. Thirteen subjects who had complete or incomplete tetraplegia for more than one year participated in the study. Eleven subjects completed the study. All were clinically stable outpatients without any history of asthma or use of inhaled bronchodilators. Following baseline measurements, patients were randomized to receive salmeterol or placebo from identically marked Diskus containers for 4 weeks. Following a 4-week washout period, the subjects were randomized to receive the alternate preparation for 4 weeks. Pulmonary function parameters and static mouth pressure were measured during baseline and during the fourth week of the two study periods. During the 4-week period of salmeterol administration, forced vital capacity, forced expiratory volume in 1 s, peak expiratory flow, MIP, and MEP improved significantly compared with placebo and baseline. Expiratory reserve volume increased significantly compared to baseline. Increases in MIP and MEP during salmeterol administration suggest improvement in respiratory muscle strength. However, this cannot be stated with certainty because MIP and MEP are dependent on volume parameters at which they are measured. Regardless of the mechanism, improvement in static mouth pressures indicates that salmeterol should benefit these individuals by improving cough effectiveness. Springer Science+Business Media, Inc., 2006 Spinal cord injury nationallicence Spirometry nationallicence Bronchodilator nationallicence Respiratory muscle strength nationallicence Salmeterol nationallicence Tetraplegia nationallicence Grimm David Basic Sciences Department, New York Chiropractic College, 13148, Seneca Falls, New York, USA aut Schilero Gregory Center for the Medical Consequences of Spinal Cord Injury, James J. Peters Veterans Affairs Medical Center, Room 1E-02, 130 West Kingsbridge Road, 10468, Bronx, New York, USA aut Spungen Ann Department of Medicine, Mount Sinai School of Medicine, 10029, New York, New York, USA aut Bauman William Department of Medicine, Mount Sinai School of Medicine, 10029, New York, New York, USA aut Lesser Marvin Center for the Medical Consequences of Spinal Cord Injury, James J. Peters Veterans Affairs Medical Center, 10468, Bronx, New York, USA aut Lung Springer-Verlag; www.springer-ny.com 184/6(2006-12-01), 335-339 0341-2040 184:6<335 2006 184 408 https://doi.org/10.1007/s00408-006-0011-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-006-0011-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grimm David Basic Sciences Department, New York Chiropractic College, 13148, Seneca Falls, New York, USA aut NATIONALLICENCE 700 1- Schilero Gregory Center for the Medical Consequences of Spinal Cord Injury, James J. Peters Veterans Affairs Medical Center, Room 1E-02, 130 West Kingsbridge Road, 10468, Bronx, New York, USA aut NATIONALLICENCE 700 1- Spungen Ann Department of Medicine, Mount Sinai School of Medicine, 10029, New York, New York, USA aut NATIONALLICENCE 700 1- Bauman William Department of Medicine, Mount Sinai School of Medicine, 10029, New York, New York, USA aut NATIONALLICENCE 700 1- Lesser Marvin Center for the Medical Consequences of Spinal Cord Injury, James J. Peters Veterans Affairs Medical Center, 10468, Bronx, New York, USA aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/6(2006-12-01), 335-339 0341-2040 184:6<335 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer