caa a22 4500 46793469X CHVBK 20180406152953.0 cr unu---uuuuu 170328e20061201xx s 000 0 eng 10.1007/s00408-006-0012-5 doi (NATIONALLICENCE)springer-10.1007/s00408-006-0012-5 Effect of Histologic Type on Recurrence Pattern in Radiation Therapy for Medically Inoperable Patients with Stage I Non-Small-Cell Lung Cancer [Elektronische Daten] [Hitoshi Ishikawa, Yuko Nakayama, Yoshizumi Kitamoto, Tetsuo Nonaka, Hidemasa Kawamura, Katsuyuki Shirai, Hideyuki Sakurai, Kazushige Hayakawa, Hideo Niibe, Takashi Nakano] Japanese randomized trials showed that there was a significant impact on survival from stage I adenocarcinoma (AD) of the lung by adjuvant chemotherapy with uracil-tegaful after complete resection but there was no effect for patients with squamous cell carcinoma (SQ). The purpose of this study was to examine the correlation of tumor histology and clinical outcome of radiation therapy (RT) for stage I non-small-cell lung cancer (NSCLC) and to consider the necessity of adjuvant chemotherapy after RT for these patients. The subjects were 83 patients, 54 with SQ and 29 with AD; they had received definitive RT with the total dose ranging from 60 to 80 Gy with conventional fractionation at a daily dose of 2 Gy. The differences between SQ and AD with respect to survival and recurrence pattern were investigated. The 5-year overall survival and cause-specific survival rates were 26.5% and 49.1%, respectively. No difference in survival was observed between SQ and AD patients, and the recurrence rates were almost identical (44% for SQ and 45% for AD). However, the 5-year primary control rate of SQ was significantly poorer than that of AD (SQ: 61.5%; AD: 87.6%; p = 0.03). Conversely, the 5-year metastasis-free survival rate of SQ was significantly better than that of AD (SQ: 88.2%; AD: 53.0%; p = 0.005). The different failure pattern, according to tumor histology, indicates that taking into consideration the difference in their clinical behaviors would also be important for planning RT and surgery for early lung cancer. Springer Science+Business Media, Inc., 2006 Non-small-cell lung cancer nationallicence Histologic type nationallicence Radiation therapy nationallicence Survival nationallicence Recurrence nationallicence Ishikawa Hitoshi Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut Nakayama Yuko Department of Radiation Oncology, Tokai University School of Medicine, 259-1193, Bohseidai, Isehara, Japan aut Kitamoto Yoshizumi Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut Nonaka Tetsuo Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut Kawamura Hidemasa Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut Shirai Katsuyuki Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut Sakurai Hideyuki Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut Hayakawa Kazushige Department of Radiology, Kitasato University, 1-15-1, Kitasato, 228-8555, Sagamihara, Kanagawa, Japan aut Niibe Hideo Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut Nakano Takashi Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut Lung Springer-Verlag; www.springer-ny.com 184/6(2006-12-01), 347-353 0341-2040 184:6<347 2006 184 408 https://doi.org/10.1007/s00408-006-0012-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-006-0012-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ishikawa Hitoshi Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Nakayama Yuko Department of Radiation Oncology, Tokai University School of Medicine, 259-1193, Bohseidai, Isehara, Japan aut NATIONALLICENCE 700 1- Kitamoto Yoshizumi Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Nonaka Tetsuo Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Kawamura Hidemasa Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Shirai Katsuyuki Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Sakurai Hideyuki Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Hayakawa Kazushige Department of Radiology, Kitasato University, 1-15-1, Kitasato, 228-8555, Sagamihara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Niibe Hideo Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Nakano Takashi Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/6(2006-12-01), 347-353 0341-2040 184:6<347 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer