caa a22 4500 467934738 CHVBK 20180406152953.0 cr unu---uuuuu 170328e20061201xx s 000 0 eng 10.1007/s00408-006-0018-z doi (NATIONALLICENCE)springer-10.1007/s00408-006-0018-z Preventive Effect of Hochu-ekki-to on Lipopolysaccharide-Induced Acute Lung Injury in BALB/c Mice [Elektronische Daten] [Shunji Tajima, Masashi Bando, Hideaki Yamasawa, Shoji Ohno, Hiroshi Moriyama, Toshinori Takada, Eiichi Suzuki, Fumitake Gejyo, Yukihiko Sugiyama] This study was designed to investigate the effect of Hochu-ekki-to (TJ-41), a Japanese herbal medicine, on the development of lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. ALI was induced in female BALB/c mice by the intranasal administration of 0.1 mg/kg LPS. The mice were divided into a group receiving normal feed and another group receiving feed mixed with TJ-41 at a dose of 1 g/kg/day for 8 weeks before LPS challenge. In the bronchoalveolar lavage fluid, the preadministration of TJ-41 caused significant reduction in the absolute number of total cells, neutrophils, and macrophages. The preadministration of TJ-41 significantly inhibited increases in the serum level of keratinocyte chemoattractant (KC), which is a murine chemotaxin for neutrophils that corresponds to human interleukin-8, with respect to its concentration at 24 h after LPS challenge. Furthermore, the histopathologic findings indicated that alveolitis with leukocyte infiltration in the alveolar space was less severe in the TJ-41-treated mice than in the control mice. These findings indicated that the preadministration of TJ-41 could show an inhibitory effect on ALI in this experimental murine system associated with the suppression of chemokine production. Springer Science+Business Media, Inc., 2006 Acute lung injury nationallicence Granulocyte-macrophage colony-stimulating factor nationallicence Hochu-ekki-to nationallicence Keratinocyte chemoattractant nationallicence Lipopolysaccharide nationallicence Tajima Shunji Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Bando Masashi Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Yamasawa Hideaki Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Ohno Shoji Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Moriyama Hiroshi Division of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan aut Takada Toshinori Division of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan aut Suzuki Eiichi Division of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan aut Gejyo Fumitake Division of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan aut Sugiyama Yukihiko Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Lung Springer-Verlag; www.springer-ny.com 184/6(2006-12-01), 318-323 0341-2040 184:6<318 2006 184 408 https://doi.org/10.1007/s00408-006-0018-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-006-0018-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tajima Shunji Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Bando Masashi Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Yamasawa Hideaki Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Ohno Shoji Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Moriyama Hiroshi Division of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan aut NATIONALLICENCE 700 1- Takada Toshinori Division of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan aut NATIONALLICENCE 700 1- Suzuki Eiichi Division of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan aut NATIONALLICENCE 700 1- Gejyo Fumitake Division of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan aut NATIONALLICENCE 700 1- Sugiyama Yukihiko Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/6(2006-12-01), 318-323 0341-2040 184:6<318 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer