caa a22 4500 467934789 CHVBK 20180406152954.0 cr unu---uuuuu 170328e20060601xx s 000 0 eng 10.1007/s00408-005-2573-0 doi (NATIONALLICENCE)springer-10.1007/s00408-005-2573-0 Role of Pleural Fluid C-Reactive Protein Concentration in Discriminating Uncomplicated Parapneumonic Pleural Effusions from Complicated Parapneumonic Effusion and Empyema [Elektronische Daten] [S. Chen, W. Chen, W. Hsu, Y. Yu, C. Shih] The aim of this study was to determine whether pleural fluid C-reactive protein (CRP) is useful in distinguishing complicated parapneumonic pleural effusion (CPPE) and empyema from uncomplicated parapneumonic pleural effusions (UPPE). A total of 69 consecutive patients with parapneumonic effusions were enrolled in the study: 29 with UPPE, 29 with CPPE, and 11 with empyema. Concentrations of standard biochemical parameters together with CRP in the pleural fluid were measured using an immunoturbidimetric assay. Pleural CRP was significantly higher in CPPE (11.6 mg/dl) and in empyema (12.2 mg/dl) than in UPPE (3.9 mg/dl). A cutoff value of 8.7 mg/dl for pleural CRP in the diagnosis of CPPE and empyema resulted in a sensitivity, specificity, and area under the receiver-operating characteristic curve (AUC) of 0.80, 0.97 and 0.94, respectively. Traditional lactic dehydrogenase (LDH) ≥ 1000 U/L and glucose ≤ 60 mg/dl can differentiate CPPE and empyema from UPPE, with the sensitivity, specificity, and AUC achieving 0.75/0.60.1.00/1.00,0.95/0.22, respectively. However, for the detection of CPPE and empyema, the combination of pleural fluid CRP ≥ 8.7 mg/dl and LDH ≥ 1000 U/L was valuable in achieving a sensitivity, specificity, and AUC of 0.97/1,00/0.95. This study suggests that measurement of pleural CRP can be useful in the workup of patients with a parapneumonic effusion in order to differentiate CPPE from UPPE. Springer Science+Business Media, Inc., 2006 C-reactive protein nationallicence parapneumonic effusion nationallicence empyema nationallicence Chen S. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No. 2, Yuh-Der Road, 404, Taichung City, Taiwan aut Chen W. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No. 2, Yuh-Der Road, 404, Taichung City, Taiwan aut Hsu W. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No. 2, Yuh-Der Road, 404, Taichung City, Taiwan aut Yu Y. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No. 2, Yuh-Der Road, 404, Taichung City, Taiwan aut Shih C. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No. 2, Yuh-Der Road, 404, Taichung City, Taiwan aut Lung Springer-Verlag; www.springer-ny.com 184/3(2006-06-01), 141-145 0341-2040 184:3<141 2006 184 408 https://doi.org/10.1007/s00408-005-2573-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2573-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen S. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No. 2, Yuh-Der Road, 404, Taichung City, Taiwan aut NATIONALLICENCE 700 1- Chen W. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No. 2, Yuh-Der Road, 404, Taichung City, Taiwan aut NATIONALLICENCE 700 1- Hsu W. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No. 2, Yuh-Der Road, 404, Taichung City, Taiwan aut NATIONALLICENCE 700 1- Yu Y. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No. 2, Yuh-Der Road, 404, Taichung City, Taiwan aut NATIONALLICENCE 700 1- Shih C. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No. 2, Yuh-Der Road, 404, Taichung City, Taiwan aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/3(2006-06-01), 141-145 0341-2040 184:3<141 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer