caa a22 4500 467934800 CHVBK 20180406152954.0 cr unu---uuuuu 170328e20060601xx s 000 0 eng 10.1007/s00408-005-2574-z doi (NATIONALLICENCE)springer-10.1007/s00408-005-2574-z Giant Cell Interstitial Pneumonia Associated with Nitrofurantoin [Elektronische Daten] [Charles Hargett, Thomas Sporn, Victor Roggli, John Hollingsworth] A case of giant cell interstitial pneumonia (GIF) that occurred in association with exposure to nitrofurantoin is presented. While the diagnosis of GIP is confirmed by histopathology, this diagnosis can be supported by the findings of bizarre multinucleated giant cells (MGC), elevated T lymphocytes, and a low T lymphocyte helper/suppressor ratio in the bronchoalveolar lavage fluid (BALF). Recognition of GIP as a rare manifestation of nitrofurantoin toxicity is important because prompt therapy may be associated with a favorable outcome. Springer Science+Business Media, Inc., 2006 Lung diseases nationallicence Interstitial nationallicence Nitrofurantoin nationallicence Drag toxicity nationallicence Giant cells nationallicence Metals nationallicence heavy nationallicence GIP : Giant cell interstitial pneumonia nationallicence MGC : Multinucleated giant cells nationallicence BALF : Bronchoalveolar lavage fluid nationallicence CT : Computed tomography nationallicence AFB : Acid fast bacilli nationallicence Hargett Charles Division of Pulmonary, Allergy, and Critical Care, Duke University Medical Center, Box 3221, 27710, Durham, NC, USA aut Sporn Thomas Department of Pathology, Duke University Medical Center, Box 3712, 27710, Durham, NC, USA aut Roggli Victor Department of Pathology, Duke University Medical Center, Box 3712, 27710, Durham, NC, USA aut Hollingsworth John Division of Pulmonary, Allergy, and Critical Care, Duke University Medical Center, Box 3136, 27710, Durham, NC, USA aut Lung Springer-Verlag; www.springer-ny.com 184/3(2006-06-01), 147-149 0341-2040 184:3<147 2006 184 408 https://doi.org/10.1007/s00408-005-2574-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2574-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hargett Charles Division of Pulmonary, Allergy, and Critical Care, Duke University Medical Center, Box 3221, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Sporn Thomas Department of Pathology, Duke University Medical Center, Box 3712, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Roggli Victor Department of Pathology, Duke University Medical Center, Box 3712, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Hollingsworth John Division of Pulmonary, Allergy, and Critical Care, Duke University Medical Center, Box 3136, 27710, Durham, NC, USA aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/3(2006-06-01), 147-149 0341-2040 184:3<147 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer