caa a22 4500 467934819 CHVBK 20180406152954.0 cr unu---uuuuu 170328e20060601xx s 000 0 eng 10.1007/s00408-005-2578-8 doi (NATIONALLICENCE)springer-10.1007/s00408-005-2578-8 Transfusion-Related Acute Lung Injury (TRALI): Current Clinical and Pathophysiologic Considerations [Elektronische Daten] [Kelly Swanson, Denis Dwyre, Jessica Krochmal, Thomas Raife] Transfusion-related acute lung injury (TRALI) is a rare transfusion reaction presenting as respiratory distress during or after transfusion of blood products. TRALI varies in severity, and mortality is not uncommon. TRALI reactions have equal gender distributions and can occur in all age groups. All blood products, except albumin, have been implicated in TRALI reactions. TRALI presents as acute respiratory compromise occurring in temporal proximity to a transfusion of a blood product. Other causes of acute lung injury should be excluded in order to definitively diagnose TRALI. Clinically and pathologically, TRALI mimics acute respiratory distress syndrome (ARDS), with neutrophil-derived inflammatory chemokines and cytokines believed to be involved in the pathogenesis of both entities. Anti-HLA and anti-neutrophil antibodies have been implicated in some cases of TRALI. Treatment for TRALI is supportive; prevention is important. It is suspected that TRALI is both underdiagnosed and underreported. One of the difficulties in the evaluation of potential TRALI reactions is, until recently, the lack of diagnostic criteria. A group of transfusion medicine experts, the American-European Consensus Conference (AECC), recently met and developed diagnostic criteria of TRALI, as well as recommendations for management of donors to prevent future TRALI reactions. In light of the AECC consensus recommendations, we report an incident of TRALI in an oncology patient as an example of the potential severity of the lung disease and the clinical and laboratory evaluation of the patient. We also review the literature on this important complication of blood transfusion that internists may encounter. Springer Science+Business Media, Inc., 2006 TRALI nationallicence Transfusion reaction nationallicence Leukocyte nationallicence Pulmonary injury nationallicence Swanson Kelly Department of Internal Medicine, University of Iowa, 200 Hawkins Drive, 52242, Iowa city, IA, US aut Dwyre Denis Department of Pathology, University of Iowa College of Medicine, C250 GH, 52242, Iowa City, IA, USA aut Krochmal Jessica Department of Pathology, University of Iowa College of Medicine, C250 GH, 52242, Iowa City, IA, USA aut Raife Thomas Department of Pathology, University of Iowa College of Medicine, C250 GH, 52242, Iowa City, IA, USA aut Lung Springer-Verlag; www.springer-ny.com 184/3(2006-06-01), 177-185 0341-2040 184:3<177 2006 184 408 https://doi.org/10.1007/s00408-005-2578-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2578-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Swanson Kelly Department of Internal Medicine, University of Iowa, 200 Hawkins Drive, 52242, Iowa city, IA, US aut NATIONALLICENCE 700 1- Dwyre Denis Department of Pathology, University of Iowa College of Medicine, C250 GH, 52242, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Krochmal Jessica Department of Pathology, University of Iowa College of Medicine, C250 GH, 52242, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Raife Thomas Department of Pathology, University of Iowa College of Medicine, C250 GH, 52242, Iowa City, IA, USA aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/3(2006-06-01), 177-185 0341-2040 184:3<177 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer