caa a22 4500 46793486X CHVBK 20180406152954.0 cr unu---uuuuu 170328e20060801xx s 000 0 eng 10.1007/s00408-005-2587-7 doi (NATIONALLICENCE)springer-10.1007/s00408-005-2587-7 A Case of Alpha-Thalassemia-2 Associated with Pulmonary Infarction [Elektronische Daten] [Seiji Hayashi, Hiroto Matsuoka, Teruo Harano, Keiko Harano, Hiroshi Nakahara, Isao Tachibana, Hiroshi Kida, Tomio Kawasaki, Shingo Kyotani, Yoshihiro Oka, Mitsunori Sakatani, Ichiro Kawase] Pulmonary infarction is an entity of medical significance that develops concurrently in beta-thalassemia but not in alpha-thalassemia. The reason for this difference is yet to be elucidated. We have evaluated a 21-year-old male alpha-thalassemia-2 patient who had profound microcytic anemia and pulmonary infarction. Analysis of the alpha-globin gene revealed -alpha3.7/alpha alpha genotype. His mother also had the same heterozygous gene deletion, though she had neither anemia nor pulmonary infarction. Since the patient had no other predisposition to pulmonary infarction, it is suggested that there is a close etiologic relationship between morphologic abnormality of the erythrocytes caused by alpha-thalassemia-2 and development of pulmonary infarction. Springer Science+Business Media, Inc., 2006 -Alpha 3.7/alpha alpha genotype nationallicence Alpha-globin gene nationallicence Alpha-thalassemia nationallicence Microcytic anemia nationallicence Pulmonary infarction nationallicence Hayashi Seiji Department of Medicine, NHO Kinki-Chuo Chest Medical Center, Sakai-city, Osaka, Japan aut Matsuoka Hiroto Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University, Graduate School of Medicine, Suita-city, Osaka, Japan aut Harano Teruo Department of Biochemistry, Kawasaki Medical School, Kurashiki-city, Okayama, Japan aut Harano Keiko Department of Biochemistry, Kawasaki Medical School, Kurashiki-city, Okayama, Japan aut Nakahara Hiroshi Nakahara Clinic, Takarazuka-city, Hyogo, Japan aut Tachibana Isao Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University, Graduate School of Medicine, Suita-city, Osaka, Japan aut Kida Hiroshi Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University, Graduate School of Medicine, Suita-city, Osaka, Japan aut Kawasaki Tomio Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita-city, Osaka, Japan aut Kyotani Shingo Department of Internal Medicine, National Cardiovascular Center, Suita-city, Osaka, Japan aut Oka Yoshihiro Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University, Graduate School of Medicine, Suita-city, Osaka, Japan aut Sakatani Mitsunori Department of Medicine, NHO Kinki-Chuo Chest Medical Center, Sakai-city, Osaka, Japan aut Kawase Ichiro Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University, Graduate School of Medicine, Suita-city, Osaka, Japan aut Lung Springer-Verlag; www.springer-ny.com 184/4(2006-08-01), 223-227 0341-2040 184:4<223 2006 184 408 https://doi.org/10.1007/s00408-005-2587-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2587-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hayashi Seiji Department of Medicine, NHO Kinki-Chuo Chest Medical Center, Sakai-city, Osaka, Japan aut NATIONALLICENCE 700 1- Matsuoka Hiroto Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University, Graduate School of Medicine, Suita-city, Osaka, Japan aut NATIONALLICENCE 700 1- Harano Teruo Department of Biochemistry, Kawasaki Medical School, Kurashiki-city, Okayama, Japan aut NATIONALLICENCE 700 1- Harano Keiko Department of Biochemistry, Kawasaki Medical School, Kurashiki-city, Okayama, Japan aut NATIONALLICENCE 700 1- Nakahara Hiroshi Nakahara Clinic, Takarazuka-city, Hyogo, Japan aut NATIONALLICENCE 700 1- Tachibana Isao Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University, Graduate School of Medicine, Suita-city, Osaka, Japan aut NATIONALLICENCE 700 1- Kida Hiroshi Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University, Graduate School of Medicine, Suita-city, Osaka, Japan aut NATIONALLICENCE 700 1- Kawasaki Tomio Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita-city, Osaka, Japan aut NATIONALLICENCE 700 1- Kyotani Shingo Department of Internal Medicine, National Cardiovascular Center, Suita-city, Osaka, Japan aut NATIONALLICENCE 700 1- Oka Yoshihiro Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University, Graduate School of Medicine, Suita-city, Osaka, Japan aut NATIONALLICENCE 700 1- Sakatani Mitsunori Department of Medicine, NHO Kinki-Chuo Chest Medical Center, Sakai-city, Osaka, Japan aut NATIONALLICENCE 700 1- Kawase Ichiro Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University, Graduate School of Medicine, Suita-city, Osaka, Japan aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/4(2006-08-01), 223-227 0341-2040 184:4<223 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer