caa a22 4500 467934916 CHVBK 20180406152954.0 cr unu---uuuuu 170328e20060801xx s 000 0 eng 10.1007/s00408-005-2582-z doi (NATIONALLICENCE)springer-10.1007/s00408-005-2582-z Single Dose of Tiotropium Improves the 6-Minute Walk Distance in Chronic Obstructive Pulmonary Disease [Elektronische Daten] [Nilsel Okudan, Mehmet Gök, Hakkı Gökbel, Mecit Süerdem] The aim of this study was to evaluate the effect of a single dose of tiotropium on the exercise capacity of stable chronic obstructive pulmonary disease (COPD) patients. The study was a randomized, placebo-controlled, double-blind, cross-over study. Forty-four stable COPD patients with moderate to severe airway obstruction were selected according to the GOLD criteria. The regular anticholinergic therapies of the patients were interrupted one week before the test. In the morning hours of the first day, half the group was given one capsule (18 mcg) of tiotropium and the other half was given placebo as inhalation using the HandiHaler® device. Before and 120min after the medication, the 6-min walk test was performed. Oxygen saturation, modified Borg dyspnea ratings, blood pressure, and heart rate were recorded before and after the test. The same procedure was repeated at the same time on the third day but this time the patients were given placebo if they used tiotropium on the first day and vice versa. Before using tiotropium or placebo there was no difference between 6-min walk distances. The 6-min walk distance after the use of tiotropium (429.3 ± 70.6 m) was significantly longer than that after the use of placebo (414.7 ± 74.6 m). The changes in Borg dyspnea ratings and arterial oxygen saturation values with tiotropium and placebo use were not significant. We conclude that exercise capacity might be improved by using a single-dose tiotropium inhalation in moderate to severe COPD patients. Springer Science+Business Media, Inc., 2006 Chronic obstructive pulmonary disease nationallicence Walking test nationallicence Tiotropium nationallicence Exercise tolerance nationallicence Exercise testing nationallicence Okudan Nilsel Meram Faculty of Medicine, Department of Physiology, Selçuk University, 42080, Konya, Turkey aut Gök Mehmet Meram Faculty of Medicine, Clinics of Chest Diseases, Selçuk University, 42080, Konya, Turkey aut Gökbel Hakkı Meram Faculty of Medicine, Department of Physiology, Selçuk University, 42080, Konya, Turkey aut Süerdem Mecit Meram Faculty of Medicine, Clinics of Chest Diseases, Selçuk University, 42080, Konya, Turkey aut Lung Springer-Verlag; www.springer-ny.com 184/4(2006-08-01), 201-204 0341-2040 184:4<201 2006 184 408 https://doi.org/10.1007/s00408-005-2582-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2582-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Okudan Nilsel Meram Faculty of Medicine, Department of Physiology, Selçuk University, 42080, Konya, Turkey aut NATIONALLICENCE 700 1- Gök Mehmet Meram Faculty of Medicine, Clinics of Chest Diseases, Selçuk University, 42080, Konya, Turkey aut NATIONALLICENCE 700 1- Gökbel Hakkı Meram Faculty of Medicine, Department of Physiology, Selçuk University, 42080, Konya, Turkey aut NATIONALLICENCE 700 1- Süerdem Mecit Meram Faculty of Medicine, Clinics of Chest Diseases, Selçuk University, 42080, Konya, Turkey aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/4(2006-08-01), 201-204 0341-2040 184:4<201 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer