caa a22 4500 467934932 CHVBK 20180406152954.0 cr unu---uuuuu 170328e20060801xx s 000 0 eng 10.1007/s00408-005-2586-8 doi (NATIONALLICENCE)springer-10.1007/s00408-005-2586-8 Inhaled Fluticasone and Salmeterol Suppress Eosinophilic Airway Inflammation in Chronic Obstructive Pulmonary Disease: Relations with Lung Function and Bronchodilator Reversibility [Elektronische Daten] [Diahn-Warng Perng, Cheng-Che Wu, Kang-Cheng Su, Yu-Chin Lee, Reury-Perng Perng, Chi-Wei Tao] The aim of this study was to determine whether combined inhaled corticosteroids and long-acting β2 agonists can suppress eosinophilic inflammation in chronic dostructive plumonary disease (COPD) and to investigate the association between the level of eosinophilia and the degree of bronchodilator reversibility. Sixty-two patients with stable COPD (forced expiratory volume in 1 [FEV1] of 30%-70% predicted before bronchodilation) were enrolled from our outpatient clinic. Patients received inhaled fluticasone (100µg)/salmeterol (50µg) twice daily for two months. Lung function measurements, bronchodilator tests, and sputum induction were performed. The number of inflammatory cells and mediators, including interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and eosinophilic cationic protein (ECP), were measured. Treatment with inhaled fluticasone and salmeterol significantly suppressed eosinophilic inflammation in COPD patients with sputum eosinophilia (mean 8.9% ± 2.0% vs. 1.6% ± 0.5%, p = 0.003), but insignificant differences in FEV1 and FVC between patients with and without eosinophilia suggested that suppression of eosinophilic inflammation had no effect on FEV1 or FVC. Reduction in the percentage of eosinophils was significantly correlated with decreased levels of ECP (r = 0.48, p < 0.001). Levels of neutrophils, IL-8, and TNF-α were not affected. Sputum eosinophilia was not related to the degree of bronchodilator reversibility. The degree of bronchodilator reversibility did not predict the increase in FEV1 and FVC after treatment with inhaled corticosteroids/long-acting β2 agonists. Suppression of eosinophilic inflammation and bronchodilator responsiveness indices were not correlated with clinical outcomes in COPD patients treated with inhaled corticosteroids/long-acting β2 agonists. Springer Science+Business Media, Inc., 2006 Eosinophilia nationallicence Inflammation nationallicence Reversibility nationallicence Corticosteroid nationallicence Lung function nationallicence Perng Diahn-Warng Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut Wu Cheng-Che Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut Su Kang-Cheng Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut Lee Yu-Chin Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut Perng Reury-Perng Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut Tao Chi-Wei School of Medicine, National Yang-Ming University, Taipei, Taiwan aut Lung Springer-Verlag; www.springer-ny.com 184/4(2006-08-01), 217-222 0341-2040 184:4<217 2006 184 408 https://doi.org/10.1007/s00408-005-2586-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2586-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Perng Diahn-Warng Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Wu Cheng-Che Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Su Kang-Cheng Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lee Yu-Chin Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Perng Reury-Perng Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Tao Chi-Wei School of Medicine, National Yang-Ming University, Taipei, Taiwan aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/4(2006-08-01), 217-222 0341-2040 184:4<217 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer