caa a22 4500 467934967 CHVBK 20180406152954.0 cr unu---uuuuu 170328e20061001xx s 000 0 eng 10.1007/s00408-005-2590-z doi (NATIONALLICENCE)springer-10.1007/s00408-005-2590-z Perception of Airway Obstruction and Airway Inflammation in Asthma: A Review [Elektronische Daten] [Elisabetta Rosi, Loredana Stendardi, Barbara Binazzi, Giorgio Scano] Dyspnea has a multifactorial nature and the exact mechanism that causes breathlessness in asthma is not fully understood. There is compelling evidence that factors other than merely mechanical ones take part in the pathophysiology of breathlessness. Some recent reports attribute airway inflammation, which may contribute to the unexplained variability in the perception of dyspnea associated with bronchoconstriction. Eosinophil airway inflammation has been proposed as a determinant of breathlessness via mechanisms affecting either the mechanical pathways that control breathlessness or the afferent nerves involved in perception of dyspnea. In this review, data on the interrelation between inflammation and dyspnea sensation and the impact of treatment on dyspnea sensation are discussed. We conclude that regardless of whether mechanical or chemical inflammatory factors are involved, much variability in dyspnea scores remains unexplained. Springer Science+Business Media, Inc., 2006 Airway inflammation nationallicence Asthma nationallicence Dyspnea nationallicence Rosi Elisabetta Section of Respiratory Medicine, Department of Medical-Surgical Specialty, University of Florence, Florence, Firenze, Italy aut Stendardi Loredana Department of Internal Medicine, Section of Immunology and Respiratory Medicine, University of Florence, Viale Morgagni 85, 50134, Firenze, Italy aut Binazzi Barbara Department of Internal Medicine, Section of Immunology and Respiratory Medicine, University of Florence, Viale Morgagni 85, 50134, Firenze, Italy aut Scano Giorgio Department of Internal Medicine, Section of Immunology and Respiratory Medicine, University of Florence, Viale Morgagni 85, 50134, Firenze, Italy aut Lung Springer-Verlag; www.springer-ny.com 184/5(2006-10-01), 251-258 0341-2040 184:5<251 2006 184 408 https://doi.org/10.1007/s00408-005-2590-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2590-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rosi Elisabetta Section of Respiratory Medicine, Department of Medical-Surgical Specialty, University of Florence, Florence, Firenze, Italy aut NATIONALLICENCE 700 1- Stendardi Loredana Department of Internal Medicine, Section of Immunology and Respiratory Medicine, University of Florence, Viale Morgagni 85, 50134, Firenze, Italy aut NATIONALLICENCE 700 1- Binazzi Barbara Department of Internal Medicine, Section of Immunology and Respiratory Medicine, University of Florence, Viale Morgagni 85, 50134, Firenze, Italy aut NATIONALLICENCE 700 1- Scano Giorgio Department of Internal Medicine, Section of Immunology and Respiratory Medicine, University of Florence, Viale Morgagni 85, 50134, Firenze, Italy aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/5(2006-10-01), 251-258 0341-2040 184:5<251 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer