caa a22 4500 467934975 CHVBK 20180406152954.0 cr unu---uuuuu 170328e20061001xx s 000 0 eng 10.1007/s00408-005-2593-9 doi (NATIONALLICENCE)springer-10.1007/s00408-005-2593-9 Clinical Characteristics of a Second Small Nodule(s) Associated with cT1-2N0M0 Non-Small-Cell Lung Cancer [Elektronische Daten] [Ho Yoon, Jae-Jun Yim, Choon-Taek Lee, Young Kim, Sung Han, Young-Soo Shim, Young Kim, Sook Sung, Joo Kim, Chul-Gyu Yoo] When a patient with cT1-2N0M0 stage non-small-cell lung cancer (NSCLC) has a second small nodule(s), the treatment plan and prognosis depend largely on whether the nodule is benign or malignant. However, the incidence of malignancy of nodules associated with N0 and M0 NSCLC is unknown. Furthermore, predictive factors of malignancy have not been defined. Thus, we evaluated the nature of nodules that were less than 15 mm in diameter associated with stage T1-2N0M0, and tried to identify clinical and radiologic factors predictive of malignancy. The study population consisted of 39 patients with T1-2N0M0 NSCLC and a second nodule(s) less than 1.5 cm and who had received curative resection. Medical records and radiologic findings, including CT scans of the chest, were retrospectively reviewed. Nodules were finally diagnosed as benign in 85% and malignant in 15%. No significant differences in terms of gender, age, preoperative carcinoembryonic antigen (CEA) level, cell type, pathologic stages, shape, size, location and number of nodules, or the presence of calcification around nodules was observed between benign and malignant groups. We suggest that if primary NSCLC is resectable, an effort should be made to confirm the pathologic diagnosis of nodules. If histologic findings in nodules are not available, surgical resection should be actively considered, especially when nodules < 1.5 cm are associated with N0 or M0 NSCLCs. Springer Science+Business Media, Inc., 2006 Nodule nationallicence Non-small-cell lung cancer nationallicence Yoon Ho Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, 463-707, Seongnam-si, Geonggi-do, Republic of Korea aut Yim Jae-Jun Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut Lee Choon-Taek Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, 463-707, Seongnam-si, Geonggi-do, Republic of Korea aut Kim Young Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut Han Sung Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut Shim Young-Soo Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut Kim Young Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut Sung Sook Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut Kim Joo Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut Yoo Chul-Gyu Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut Lung Springer-Verlag; www.springer-ny.com 184/5(2006-10-01), 273-278 0341-2040 184:5<273 2006 184 408 https://doi.org/10.1007/s00408-005-2593-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2593-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoon Ho Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, 463-707, Seongnam-si, Geonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Yim Jae-Jun Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Lee Choon-Taek Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, 463-707, Seongnam-si, Geonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Kim Young Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Han Sung Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Shim Young-Soo Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kim Young Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Sung Sook Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kim Joo Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Yoo Chul-Gyu Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Hospital, 28 Yongon-dong, 110-744, Chongno-gu, Seoul, Republic of Korea aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/5(2006-10-01), 273-278 0341-2040 184:5<273 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer