caa a22 4500 467935025 CHVBK 20180406152954.0 cr unu---uuuuu 170328e20060401xx s 000 0 eng 10.1007/s00408-005-2569-9 doi (NATIONALLICENCE)springer-10.1007/s00408-005-2569-9 Pleurodesis Induced by Talc or Silver Nitrate: Evaluation of Collagen and Elastic Fibers in Pleural Remodeling [Elektronische Daten] [Leila Antonangelo, Francisco Vargas, Lisete Teixeira, Milena Acencio, Marcelo Vaz, Mário Filho, Evaldo Marchi] This study evaluated the extracellular matrix (collagen and elastic fibers) in pleurodesis induced by intrapleural talc (TL) or silver nitrate (SN). Study subjects were 420 rabbits divided into two groups and sacrificed from 15 min to 12 months after the injection of the sclerosing agents at intervals previously defined. Pleural adhesions and fibrosis were graded (0-4), and the collagen and elastin were quantified. The maximum score of the pleural adhesions was observed two months after TL (2.80 ± 0.99) and 15 days after SN (3.75 ± 0.25). More intense pleural adhesions were observed in the SN group from day 5 (p < 0.05). Pleural thickness and pleural fibrosis were, in general, significantly higher after SN (p < 0.05). Increased deposition of collagen and elastin was observed in both groups but was more evident in the SN group. In the TL group, a linear correlation was observed between pleural adhesions and fibrosis (r = 0.775), between pleural adhesions and collagen (r = 0.779), and between fibrosis and collagen (r = 0.709). In the SN group, these correlations were acceptable (r = 0.605, 0.665, and 0.663). The elastin presented a correlation of 0.707 (p < 0.001) in the TL group and of 0.564 (p < 0.001) in the SN group. In conclusion, intrapleural 0.5% silver nitrate and talc (400 mg/kg) are effective in the induction of pleurodesis. However, the intensity of adhesions and the richness of collagen after SN, in combination with the early onset of tissue remodeling, demonstrate the local superiority of this agent. Considering the easy availability and instillation, the low cost, and the absence of important side effects, silver nitrate might be considered as a sclerosing agent to induce pleurodesis in humans. Springer Science+Business Media, Inc., 2006 Pleurodesis nationallicence Pleural remodeling nationallicence Collagen nationallicence Silver nitrate nationallicence Intrapleural talc nationallicence Antonangelo Leila Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut Vargas Francisco Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut Teixeira Lisete Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut Acencio Milena Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut Vaz Marcelo Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut Filho Mário Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut Marchi Evaldo Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut Lung Springer-Verlag; www.springer-ny.com 184/2(2006-04-01), 105-111 0341-2040 184:2<105 2006 184 408 https://doi.org/10.1007/s00408-005-2569-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2569-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Antonangelo Leila Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut NATIONALLICENCE 700 1- Vargas Francisco Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut NATIONALLICENCE 700 1- Teixeira Lisete Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut NATIONALLICENCE 700 1- Acencio Milena Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut NATIONALLICENCE 700 1- Vaz Marcelo Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut NATIONALLICENCE 700 1- Filho Mário Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut NATIONALLICENCE 700 1- Marchi Evaldo Laboratory of Pleura-Pulmonary Division and Division of Applied Physiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/2(2006-04-01), 105-111 0341-2040 184:2<105 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer