caa a22 4500 467935041 CHVBK 20180406152954.0 cr unu---uuuuu 170328e20060401xx s 000 0 eng 10.1007/s00408-005-2564-1 doi (NATIONALLICENCE)springer-10.1007/s00408-005-2564-1 Effects of Early Intervention with Inhaled Sodium Cromoglycate in Childhood Asthma [Elektronische Daten] [S. Yoshihara, N. Kanno, Y. Yamada, M. Ono, N. Fukuda, M. Numata, T. Abe, O. Arisaka] International and Japanese guidelines classify childhood asthma as mild, moderate, or severe, and recommend treatment with "as needed” bronchodilators, inhaled sodium cromoglycate, and inhaled corticosteroids, respectively. Alternatively, some investigators proposed inhaled corticosteroids as first-line therapy to prevent airway inflammatory obstruction. This article describes a clinical study assessing the effect of early intervention with inhaled sodium cromoglycate in childhood asthma. This was a retrospective study of 189 asthmatic children treated with inhaled sodium cromoglycate for five years and whose age of onset of asthma was six year of age or younger. An end-of-study questionnaire completed the examination. Children administered oral or inhaled corticosteroids simultaneously with sodium cromoglycate, were excluded. Asthma scores as defined by the Japanese Pediatric Allergic Committee, were reduced continuously during the five years after the start of sodium cromoglycate treatment. The frequency of emergency department visits and hospitalizations also decreased. Significant between-period intervention differences showed improvement of clinical outcomes for children with severe asthma during the five years of sodium cromoglycate inhalation. The early intervention regime of starting sodium cromoglycate inhalation within two years of the onset of asthma shows a large improvement in the long-term prognosis of childhood asthma, especially for children with severe asthma. It is possible that starting inhaled sodium cromoglycate earlier than the present recommendation of corticosteroids could further improve clinical outcomes, but a prospective study should be performed to verify our results. Springer Science+Business Media, Inc., 2006 Sodium cromoglycate nationallicence Children nationallicence Asthma nationallicence Early intervention nationallicence Clinical study nationallicence Yoshihara S. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut Kanno N. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut Yamada Y. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut Ono M. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut Fukuda N. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut Numata M. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut Abe T. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut Arisaka O. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut Lung Springer-Verlag; www.springer-ny.com 184/2(2006-04-01), 63-72 0341-2040 184:2<63 2006 184 408 https://doi.org/10.1007/s00408-005-2564-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2564-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoshihara S. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut NATIONALLICENCE 700 1- Kanno N. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut NATIONALLICENCE 700 1- Yamada Y. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut NATIONALLICENCE 700 1- Ono M. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut NATIONALLICENCE 700 1- Fukuda N. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut NATIONALLICENCE 700 1- Numata M. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut NATIONALLICENCE 700 1- Abe T. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut NATIONALLICENCE 700 1- Arisaka O. Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/2(2006-04-01), 63-72 0341-2040 184:2<63 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer