caa a22 4500 46793505X CHVBK 20180406152954.0 cr unu---uuuuu 170328e20060401xx s 000 0 eng 10.1007/s00408-005-2562-3 doi (NATIONALLICENCE)springer-10.1007/s00408-005-2562-3 Technetium-99m Hexamethylpropylene Amine Oxime Lung Scintigraphy Findings in Low-Dose Amiodarone Therapy [Elektronische Daten] [G. Kaya, T. Ertay, B. Tuna, R. Bekis, C. Tasci, E. Sayit, O. Yılmaz, A. Kargı, H. Durak] Amiodarone (AD)-induced pulmonary toxicity is one of the major complications of long-term AD therapy. Technetium-99m-labeled D,L-hexamethylpropylene amine oxime (Tc-99m HMPAO) scintigraphy has been used to assess lung injury. We designed this study to clarify lung uptake changes of Tc-99m HMPAO using low doses of AD (5 mg/kg/day) during long-term therapy in a rabbit model. Group 1 consisted of 7 rabbits fed with AD by gavage for 6 months. To investigate the effect of ketamine on Tc-99m HMPAO uptake, 5 rabbits were included in Group 2 as a control group. Tc-99m HMPAO scintigraphy was performed in both Group 1 and Group 2 at baseline and after 2, 4, 6, 8, and 12 weeks of AD intake. After 16, 20, and 24 weeks of drug intake, Tc-99m HMPAO scintigraphy was repeated only in group 1. One-min anterior images were acquired 30 min after the injection of 37 MBq of Tc-99m HMPAO. For semiquantitative evaluation, the mean count values were obtained and lung/background and liver/background ratios were calculated. Histopathologic evaluation was performed. No increase in lung and liver uptake of Tc-99m HMPAO was found 2, 4, 6, 8, and 12 weeks after drug intake. There was no significant increase in L/B and H/B ratios of Tc-99m HMPAO in Group 1 compared with Group 2. Both scintigraphic studies and histopathologic examinations showed nonspecific changes. Longitudinal studies investigating Tc-99m HMPAO lung uptake may be planned in patients carrying risk factors for AD-induced lung toxicity. Springer Science+Business Media, Inc., 2006 Tc-99m HMPAO nationallicence Amiodarone nationallicence Lung nationallicence Toxicity nationallicence Inflammation nationallicence Kaya G. Department of Nuclear Medicine, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut Ertay T. Department of Nuclear Medicine, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut Tuna B. Department of Pathology, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut Bekis R. Department of Nuclear Medicine, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut Tasci C. Department of Nuclear Medicine, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut Sayit E. Department of Nuclear Medicine, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut Yılmaz O. Animal Research Center, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut Kargı A. Department of Pathology, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut Durak H. Department of Nuclear Medicine, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut Lung Springer-Verlag; www.springer-ny.com 184/2(2006-04-01), 57-61 0341-2040 184:2<57 2006 184 408 https://doi.org/10.1007/s00408-005-2562-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2562-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kaya G. Department of Nuclear Medicine, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut NATIONALLICENCE 700 1- Ertay T. Department of Nuclear Medicine, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut NATIONALLICENCE 700 1- Tuna B. Department of Pathology, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut NATIONALLICENCE 700 1- Bekis R. Department of Nuclear Medicine, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut NATIONALLICENCE 700 1- Tasci C. Department of Nuclear Medicine, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut NATIONALLICENCE 700 1- Sayit E. Department of Nuclear Medicine, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut NATIONALLICENCE 700 1- Yılmaz O. Animal Research Center, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut NATIONALLICENCE 700 1- Kargı A. Department of Pathology, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut NATIONALLICENCE 700 1- Durak H. Department of Nuclear Medicine, Dokuz Eylül University, School of Medicine, Izmir, Turkey aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/2(2006-04-01), 57-61 0341-2040 184:2<57 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer