caa a22 4500 467935068 CHVBK 20180406152954.0 cr unu---uuuuu 170328e20060401xx s 000 0 eng 10.1007/s00408-005-2565-0 doi (NATIONALLICENCE)springer-10.1007/s00408-005-2565-0 Relationship Among Pulmonary Function, Bronchial Hyperresponsiveness, and Atopy in Children with Clinically Stable Asthma [Elektronische Daten] [Eugene Yang, Woojung Kim, Byoung Kwon, Sung Choi, Myung Sohn, Kyu-Earn Kim] Pulmonary function testing plays a key role in the diagnosis and management of asthma in children. However, the literature does not clearly show whether children with clinically stable asthma have significantly reduced lung function when compared with normal children. We compared the lung function of 242 clinically stable asthmatic children who were initially diagnosed with mild intermittent or mild persistent asthma with the lung function of 100 nonasthmatic controls. The lung function was assessed using FEV1, FEV1/FVC, FEF25-75 and PEF. In addition, we measured bronchial hyperresponsiveness (BHR) using the provocation concentration of methacholine needed to produce a 20% fall in FEV1. All measures of pulmonary function were significantly decreased in the children with asthma. Pulmonary function was not influenced by atopy, serum IgE, or total eosinophil count (TEC). However, the likelihood ratio for trends revealed a significant association between our pulmonary parameters and the degree of BHR. Children with mild-to-severe BHR had greatly decreased lung function compared with those with normal BHR, the control group. In addition, a direct correlation was found between PC20 and our pulmonary parameters in asthmatic children. However, only atopic children with asthma had a significant correlation between PC20 and TEC. We found children with clinically stable asthma to have pulmonary obstruction, which associated strongly with their degree of BHR. Springer Science+Business Media, Inc., 2006 Asthma nationallicence Pulmonary function nationallicence Bronchial hyperresponsiveness nationallicence Atopy nationallicence Yang Eugene Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, CPO Box 8044, 120-752, Seoul, South Korea aut Kim Woojung Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, CPO Box 8044, 120-752, Seoul, South Korea aut Kwon Byoung Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, CPO Box 8044, 120-752, Seoul, South Korea aut Choi Sung Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, CPO Box 8044, 120-752, Seoul, South Korea aut Sohn Myung Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, CPO Box 8044, 120-752, Seoul, South Korea aut Kim Kyu-Earn Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, CPO Box 8044, 120-752, Seoul, South Korea aut Lung Springer-Verlag; www.springer-ny.com 184/2(2006-04-01), 73-79 0341-2040 184:2<73 2006 184 408 https://doi.org/10.1007/s00408-005-2565-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2565-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Eugene Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, CPO Box 8044, 120-752, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Woojung Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, CPO Box 8044, 120-752, Seoul, South Korea aut NATIONALLICENCE 700 1- Kwon Byoung Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, CPO Box 8044, 120-752, Seoul, South Korea aut NATIONALLICENCE 700 1- Choi Sung Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, CPO Box 8044, 120-752, Seoul, South Korea aut NATIONALLICENCE 700 1- Sohn Myung Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, CPO Box 8044, 120-752, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Kyu-Earn Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, CPO Box 8044, 120-752, Seoul, South Korea aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/2(2006-04-01), 73-79 0341-2040 184:2<73 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer