caa a22 4500 467935076 CHVBK 20180406152954.0 cr unu---uuuuu 170328e20060401xx s 000 0 eng 10.1007/s00408-005-2570-3 doi (NATIONALLICENCE)springer-10.1007/s00408-005-2570-3 The Effects of Age on Exhaled Breath Nitric Oxide Levels [Elektronische Daten] [Robert Haight, Robert Gordon, Stuart Brooks] A variety of factors influence exhaled breath nitric oxide (ENO) but few studies have examined ENO at the extremes of adult age. This investigation explores whether there is a difference in ENO between groups of older and younger individuals. A total of 48 normal subjects consisting of 23 younger (median age - 24 years) and 25 older (median age - 72 years) participants were studied. Carefully defined clinical and spirometric parameters, smoking history, and drug/medication documentation were determined to insure normalcy. Measurements of ENO were made using ATS/ERS recommended methodologies. The older group consistently showed higher ENO concentrations than-the younger subjects; median ENO values were 36.9 and 18.7 ppb, respectively (p < 0.001). The statistical significance held true when adjusting for multiple testing with the Holm method and accounting for outliers and medication usage. ENO levels are significantly higher in a normal older population. Comparing ENO between individuals at the extremes of age may depict differences more decidedly. Whether elevated ENO reflects underlying airway inflammation in older persons remains unanswered. It is possible that the difference in NO concentrations between older and younger groups represents only a marker of past oxidant exposures and holds no clinical significance. Additional investigations are necessary to elucidate the mechanisms and significances of elevated NO levels in the aged. Springer Science+Business Media, Inc., 2006 Nitric oxide nationallicence Aging nationallicence Immunity nationallicence Breath tests nationallicence Haight Robert Department of Environmental and Occupational Health, College of Public Health, and Department of Internal Medicine, Divisions of Allergy and Clinical Immunology and Pulmonary and Critical Care Medicine, College of Medicine, University of South Florida, Tampa, Florida aut Gordon Robert Department of Environmental and Occupational Health, College of Public Health, and Department of Internal Medicine, Divisions of Allergy and Clinical Immunology and Pulmonary and Critical Care Medicine, College of Medicine, University of South Florida, Tampa, Florida aut Brooks Stuart Department of Environmental and Occupational Health, College of Public Health, and Department of Internal Medicine, Divisions of Allergy and Clinical Immunology and Pulmonary and Critical Care Medicine, College of Medicine, University of South Florida, Tampa, Florida aut Lung Springer-Verlag; www.springer-ny.com 184/2(2006-04-01), 113-119 0341-2040 184:2<113 2006 184 408 https://doi.org/10.1007/s00408-005-2570-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00408-005-2570-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Haight Robert Department of Environmental and Occupational Health, College of Public Health, and Department of Internal Medicine, Divisions of Allergy and Clinical Immunology and Pulmonary and Critical Care Medicine, College of Medicine, University of South Florida, Tampa, Florida aut NATIONALLICENCE 700 1- Gordon Robert Department of Environmental and Occupational Health, College of Public Health, and Department of Internal Medicine, Divisions of Allergy and Clinical Immunology and Pulmonary and Critical Care Medicine, College of Medicine, University of South Florida, Tampa, Florida aut NATIONALLICENCE 700 1- Brooks Stuart Department of Environmental and Occupational Health, College of Public Health, and Department of Internal Medicine, Divisions of Allergy and Clinical Immunology and Pulmonary and Critical Care Medicine, College of Medicine, University of South Florida, Tampa, Florida aut NATIONALLICENCE 773 0- Lung Springer-Verlag; www.springer-ny.com 184/2(2006-04-01), 113-119 0341-2040 184:2<113 2006 184 408 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer