caa a22 4500 467935416 CHVBK 20180406152955.0 cr unu---uuuuu 170328e20060501xx s 000 0 eng 10.1007/s10729-006-7660-0 doi (NATIONALLICENCE)springer-10.1007/s10729-006-7660-0 A stochastic model to evaluate options for antenatal genetic screening [Elektronische Daten] [Steve Gallivan, Mark Jit, Martin Utley] Haemoglobinopathies are a group of genetic disorders which are particularly prevalent among certain risk groups such as ethnic groups. Antenatal screening of potential haemoglobinopathy carriers allows early diagnosis for affected fetuses, leading to therapeutic intervention or termination. However, it has drawbacks such as screening costs and possible miscarriage as a result of fetal testing. This paper describes a model that allows the outcomes of a screening programme to be estimated for different risk groups. The model has been implemented as a computer package that can be used to inform decisions made by health care planners. Springer Science + Business Media, Inc., 2006 Haemoglobinopathies nationallicence Genetic screening nationallicence Antenatal screening nationallicence Mathematical modelling nationallicence Stochastic models nationallicence Computer models nationallicence Gallivan Steve Clinical Operational Research Unit, Department of Mathematics, University College London, Gower Street, WC1E 6BT, London, UK aut Jit Mark Clinical Operational Research Unit, Department of Mathematics, University College London, Gower Street, WC1E 6BT, London, UK aut Utley Martin Clinical Operational Research Unit, Department of Mathematics, University College London, Gower Street, WC1E 6BT, London, UK aut Health Care Management Science Kluwer Academic Publishers 9/2(2006-05-01), 111-124 1386-9620 9:2<111 2006 9 10729 https://doi.org/10.1007/s10729-006-7660-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10729-006-7660-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gallivan Steve Clinical Operational Research Unit, Department of Mathematics, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 700 1- Jit Mark Clinical Operational Research Unit, Department of Mathematics, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 700 1- Utley Martin Clinical Operational Research Unit, Department of Mathematics, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 773 0- Health Care Management Science Kluwer Academic Publishers 9/2(2006-05-01), 111-124 1386-9620 9:2<111 2006 9 10729 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer