caa a22 4500 467935696 CHVBK 20180406152956.0 cr unu---uuuuu 170328e20061001xx s 000 0 eng 10.1007/s00455-006-9052-5 doi (NATIONALLICENCE)springer-10.1007/s00455-006-9052-5 Assessment of Swallowing by Oropharyngoesophageal Scintigraphy in Patients with Amyotrophic Lateral Sclerosis [Elektronische Daten] [Bruno Fattori, Mariano Grosso, Paolo Bongioanni, Andrea Nacci, Renza Cristofani, Abedallatif AlSharif, Rosaria Licitra, Fabio Matteucci, Bruno Rossi, Domenico Rubello, Francesco Ursino, Giuliano Mariani] Amyotrophic lateral sclerosis (ALS) is the most common degenerative motor neuron disease in adults, and dysphagia is one of its most frequent and disabling symptoms. Oropharyngoesophageal scintigraphy (OPES) permits a functional and semiquantitative study of the various stages of swallowing. We studied 28 ALS patients (12 females and 16 males; mean age = 63.57 ± 10.39 yr SD), who were clinically rated against the ALSFRS scale (Amyotrophic Lateral Sclerosis Functioning Rating Scale) and underwent OPES with 99mTc-nanocolloid using either a liquid or a semisolid bolus. The semiquantitative parameters we analyzed were Oral Transit Time (OTT), Pharyngeal Transit Time (PTT), Esophageal Transit Time (ETT), Retention Index (RI), and Esophageal Emptying Rate (EER10s). Hence, the OPES performed with a semisolid bolus produced a higher proportion of pathologic values for the swallowing variables than when liquid bolus was used. Analyzed by grouping the patients into classes according to their bulbar ALSFRS scores, we found a significant increase in the OTT (p < 0.005), PTT (p < 0.02), and Oropharyngeal Retention Index (OPRI) (p < 0.0004) variables in ALS patients with more severe bulbar involvement. OPES has turned out to be a very important examination for detecting tracheal-bronchial inhalation and it also offers the possibility of acquiring a semiquantitative evaluation of the amount of food inhaled. In our experience, OPES in patients with ALS has been easy to use, economic, well tolerated, and capable of supplying precise indications with regard to the extent of the swallowing disorder, which permits a better clinical definition of the ALS patient. Springer Science+Business Media, Inc., 2007 Amyotrophic lateral sclerosis nationallicence Scintigraphy nationallicence Dysphagia nationallicence Deglutition nationallicence Deglutition disorders nationallicence Fattori Bruno Department of Neuroscience, ENT Unit, University of Pisa, Pisa, Italy aut Grosso Mariano Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy aut Bongioanni Paolo Department of Neuroscience, Neurorehabilitation Unit, University of Pisa, Pisa, Italy aut Nacci Andrea Department of Neuroscience, ENT Unit, University of Pisa, Pisa, Italy aut Cristofani Renza Department of Experimental Pathology, Medical Biotechnology, Infective Disease and Epidemiology, University of Pisa, Pisa, Italy aut AlSharif Abedallatif Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy aut Licitra Rosaria Department of Neuroscience, Neurorehabilitation Unit, University of Pisa, Pisa, Italy aut Matteucci Fabio Department of Neuroscience, ENT Unit, University of Pisa, Pisa, Italy aut Rossi Bruno Department of Neuroscience, Neurorehabilitation Unit, University of Pisa, Pisa, Italy aut Rubello Domenico Nuclear Medicine Service, "S. Maria della Misericordia” Hospital, Rovigo, Italy aut Ursino Francesco Department of Neuroscience, ENT Unit, University of Pisa, Pisa, Italy aut Mariani Giuliano Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy aut Dysphagia Springer-Verlag 21/4(2006-10-01), 280-286 0179-051X 21:4<280 2006 21 455 https://doi.org/10.1007/s00455-006-9052-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00455-006-9052-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fattori Bruno Department of Neuroscience, ENT Unit, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Grosso Mariano Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Bongioanni Paolo Department of Neuroscience, Neurorehabilitation Unit, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Nacci Andrea Department of Neuroscience, ENT Unit, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Cristofani Renza Department of Experimental Pathology, Medical Biotechnology, Infective Disease and Epidemiology, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- AlSharif Abedallatif Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Licitra Rosaria Department of Neuroscience, Neurorehabilitation Unit, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Matteucci Fabio Department of Neuroscience, ENT Unit, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Rossi Bruno Department of Neuroscience, Neurorehabilitation Unit, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Rubello Domenico Nuclear Medicine Service, "S. Maria della Misericordia” Hospital, Rovigo, Italy aut NATIONALLICENCE 700 1- Ursino Francesco Department of Neuroscience, ENT Unit, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Mariani Giuliano Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy aut NATIONALLICENCE 773 0- Dysphagia Springer-Verlag 21/4(2006-10-01), 280-286 0179-051X 21:4<280 2006 21 455 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer