caa a22 4500 467939950 CHVBK 20180406153009.0 cr unu---uuuuu 170328e20060901xx s 000 0 eng 10.1007/s00421-006-0256-z doi (NATIONALLICENCE)springer-10.1007/s00421-006-0256-z Midrio Menotti Department of Human Anatomy and Physiology, Section of Physiology, University of Padua, via Marzolo 3, 35131, Padova, Italy aut The denervated muscle: facts and hypotheses. A historical review [Elektronische Daten] [Menotti Midrio] Denervation changes in skeletal muscle (atrophy; alterations of myofibrillar expression, muscle membrane electrical properties, ACh sensitivity and excitation-contraction coupling process; fibrillation), and their possible causes are reviewed. All changes can be counteracted by muscle electrostimulation, while denervation-like effects can be caused by the complete conduction block in muscle nerve. These results do not support the hypothesis that the lack of neurotrophic, non-motor factors plays a role in denervation phenomena. Instead they support the view that the lack of neuromotor discharge is the only cause of the phenomena and that neuromotor activity is an essential factor in regulating muscle properties. However, some experimental results cannot apparently be explained by the lack of neuromotor impulses, and may still suggest that neurotrophic influences exist. A hypothesis is that neurotrophic factors, too feeble to maintain a role in completely differentiated, adult muscles, can concur with neuromotor activity in the differentiation of immature, developing muscles. Springer-Verlag, 2006 Skeletal muscle nationallicence Denervation nationallicence Neurotrophic factors nationallicence European Journal of Applied Physiology Springer-Verlag 98/1(2006-09-01), 1-21 1439-6319 98:1<1 2006 98 421 https://doi.org/10.1007/s00421-006-0256-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0256-z text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Midrio Menotti Department of Human Anatomy and Physiology, Section of Physiology, University of Padua, via Marzolo 3, 35131, Padova, Italy aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 98/1(2006-09-01), 1-21 1439-6319 98:1<1 2006 98 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer