caa a22 4500 467939977 CHVBK 20180406153009.0 cr unu---uuuuu 170328e20061201xx s 000 0 eng 10.1007/s00421-006-0300-z doi (NATIONALLICENCE)springer-10.1007/s00421-006-0300-z Hypertrophy with unilateral resistance exercise occurs without increases in endogenous anabolic hormone concentration [Elektronische Daten] [Sarah Wilkinson, Mark Tarnopolsky, Emily Grant, Caroline Correia, Stuart Phillips] We aimed to gain insight into the role that the transitory increases in anabolic hormones play in muscle hypertrophy with unilateral resistance training. Ten healthy young male subjects (21.8±0.4years, 1.78±0.04m, 75.6±2.9kg; mean±SE) engaged in unilateral resistance training for 8week (3days/week). Exercises were knee extension and leg press performed at 80-90% of the subject's single repetition maximum (1RM). Blood samples were collected in the acute period before and after the first training bout and following the last training bout and analyzed for total testosterone, free-testosterone, luteinizing hormone, sex hormone binding globulin, growth hormone, cortisol, and insulin-like growth factor-1. Thigh muscle cross sectional area (CSA) and muscle fibre CSA by biopsy (vastus lateralis) were measured pre- and post-training. Acutely, no changes in systemic hormone concentrations were observed in the 90min period following exercise and there was no influence of training on these results. Training-induced increases were observed in type IIx and IIa muscle fibre CSA of 22±3 and 13±2% (both P<0.001). No changes were observed in fibre CSA in the untrained leg (all P>0.5). Whole muscle CSA increased by 5.4±0.9% in the trained leg (P<0.001) and remained unchanged in the untrained leg (P=0.76). Isotonic 1RM increased in the trained leg for leg press and for knee extension (P<0.001). No changes were seen in the untrained leg. In conclusion, unilateral training induced local muscle hypertrophy only in the exercised limb, which occurred in the absence of changes in systemic hormones that ostensibly play a role in muscle hypertrophy. Springer-Verlag, 2006 Testosterone nationallicence Growth hormone nationallicence Strength nationallicence Weightlifting nationallicence Wilkinson Sarah Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main St. West, L8S 4K1, Hamilton, ON, Canada aut Tarnopolsky Mark Pediatrics and Neurology, McMaster University, Hamilton, ON, Canada aut Grant Emily Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main St. West, L8S 4K1, Hamilton, ON, Canada aut Correia Caroline Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main St. West, L8S 4K1, Hamilton, ON, Canada aut Phillips Stuart Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main St. West, L8S 4K1, Hamilton, ON, Canada aut European Journal of Applied Physiology Springer-Verlag 98/6(2006-12-01), 546-555 1439-6319 98:6<546 2006 98 421 https://doi.org/10.1007/s00421-006-0300-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0300-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wilkinson Sarah Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main St. West, L8S 4K1, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Tarnopolsky Mark Pediatrics and Neurology, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Grant Emily Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main St. West, L8S 4K1, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Correia Caroline Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main St. West, L8S 4K1, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Phillips Stuart Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main St. West, L8S 4K1, Hamilton, ON, Canada aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 98/6(2006-12-01), 546-555 1439-6319 98:6<546 2006 98 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer