caa a22 4500 467940010 CHVBK 20180406153009.0 cr unu---uuuuu 170328e20061201xx s 000 0 eng 10.1007/s00421-006-0296-4 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0296-4 Changes in markers of muscle damage, inflammation and HSP70 after an Ironman triathlon race [Elektronische Daten] [Katsuhiko Suzuki, Jonathan Peake, Kazunori Nosaka, Mitsuharu Okutsu, Chris Abbiss, Rob Surriano, David Bishop, Marc Quod, Hamilton Lee, David Martin, Paul Laursen] We investigated the effects of an Ironman triathlon race on markers of muscle damage, inflammation and heat shock protein 70 (HSP70). Nine well-trained male triathletes (mean±SD age 34±5years; V̇O2peak 66.4mlkg−1min−1) participated in the 2004 Western Australia Ironman triathlon race (3.8km swim, 180km cycle, 42.2km run). We assessed jump height, muscle strength and soreness, and collected venous blood samples 2days before the race, within 30min and 14-20h after the race. Plasma samples were analysed for muscle proteins, acute phase proteins, cytokines, heat shock protein 70 (HSP70), and clinical biochemical variables related to dehydration, haemolysis, liver and renal functions. Muscular strength and jump height decreased significantly (P<0.05) after the race, whereas muscle soreness and the plasma concentrations of muscle proteins increased. The cytokines interleukin (IL)-1 receptor antagonist, IL-6 and IL-10, and HSP70 increased markedly after the race, while IL-12p40 and granulocyte colony-stimulating factor (G-CSF) were also elevated. IL-4, IL-1β and tumour necrosis factor-α did not change significantly, despite elevated C-reactive protein and serum amyloid protein A on the day after the race. Plasma creatinine, uric acid and total bilirubin concentrations and γ-glutamyl transferase activity also changed after the race. In conclusion, despite evidence of muscle damage and an acute phase response after the race, the pro-inflammatory cytokine response was minimal and anti-inflammatory cytokines were induced. HSP70 is released into the circulation as a function of exercise duration. Springer-Verlag, 2006 Ultraendurance exercise nationallicence Acute phase proteins nationallicence Cytokines nationallicence Heat shock protein 70 nationallicence Systemic stress nationallicence Suzuki Katsuhiko Faculty of Human Sciences, Waseda University, 2-579-15 Mikajima Saitama, 359-1192, Tokorozawa, Saitama, Japan aut Peake Jonathan Faculty of Human Sciences, Waseda University, 2-579-15 Mikajima Saitama, 359-1192, Tokorozawa, Saitama, Japan aut Nosaka Kazunori School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia aut Okutsu Mitsuharu Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, Tokorozawa, Japan aut Abbiss Chris School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia aut Surriano Rob School of Human Movement and Exercise Science, University of Western Australia, Perth, Australia aut Bishop David School of Human Movement and Exercise Science, University of Western Australia, Perth, Australia aut Quod Marc Department of Physiology, Australian Institute of Sport, Canberra, Australia aut Lee Hamilton Department of Physiology, Australian Institute of Sport, Canberra, Australia aut Martin David Department of Physiology, Australian Institute of Sport, Canberra, Australia aut Laursen Paul School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia aut European Journal of Applied Physiology Springer-Verlag 98/6(2006-12-01), 525-534 1439-6319 98:6<525 2006 98 421 https://doi.org/10.1007/s00421-006-0296-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0296-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suzuki Katsuhiko Faculty of Human Sciences, Waseda University, 2-579-15 Mikajima Saitama, 359-1192, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 700 1- Peake Jonathan Faculty of Human Sciences, Waseda University, 2-579-15 Mikajima Saitama, 359-1192, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 700 1- Nosaka Kazunori School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia aut NATIONALLICENCE 700 1- Okutsu Mitsuharu Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, Tokorozawa, Japan aut NATIONALLICENCE 700 1- Abbiss Chris School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia aut NATIONALLICENCE 700 1- Surriano Rob School of Human Movement and Exercise Science, University of Western Australia, Perth, Australia aut NATIONALLICENCE 700 1- Bishop David School of Human Movement and Exercise Science, University of Western Australia, Perth, Australia aut NATIONALLICENCE 700 1- Quod Marc Department of Physiology, Australian Institute of Sport, Canberra, Australia aut NATIONALLICENCE 700 1- Lee Hamilton Department of Physiology, Australian Institute of Sport, Canberra, Australia aut NATIONALLICENCE 700 1- Martin David Department of Physiology, Australian Institute of Sport, Canberra, Australia aut NATIONALLICENCE 700 1- Laursen Paul School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 98/6(2006-12-01), 525-534 1439-6319 98:6<525 2006 98 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer