caa a22 4500 467940053 CHVBK 20180406153009.0 cr unu---uuuuu 170328e20061201xx s 000 0 eng 10.1007/s00421-006-0304-8 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0304-8 Effect of exercise on postprandial lipemia in men with hypertriglyceridemia [Elektronische Daten] [John Zhang, Lisa Ji, Vicki Fretwell, Guadalupe Nunez] We examined the effect of exercise on postprandial lipemia (PPL) and insulin resistance in individuals with metabolic syndrome. Subjects were 10 hypertriglyceridemia (HTG) males with insulin resistance [age=40.1±2.2years, body weight=96.3±3.3kg, fasting triglyceride (TG)=263±25mg/dl, VO2max=37±1.1ml/kg/min, and Homeostatic Model Assessment (HOMA-IR, an index of insulin resistance)=3.05±0.40]. Each subject performed a control trial (Ctr, no exercise), and three exercise trials at 40% (40%T), 60% (60%T), and 70% (70%T) of their VO2max. The order of trials was randomized and there were 1-2weeks wash-out period between the trials. All subjects had a fat-meal in each trial. In the exercise trials, subjects jogged on a treadmill for 1h at a designated intensity 12h prior to a fat-meal ingestion. Blood samples were taken at 0h (before the meal), and 2, 4, 6, and 8h after the meal. The plasma TG, area score under TG concentration curve for over an 8h-period (TG AUC) after the meal, and HOMA-IR were analyzed. The TG AUC score in 40%T was 30% lower (P=0.003), 60%T was 31% lower (P=0.02), and 70%T was 39% lower (P=0.02) than Ctr. There were no significant differences in the TG AUC scores among the exercise trials (P>0.05). The insulin concentrations in both 60 and 70%T were lower than Ctr (P<0.01) which did not differ from 40%T. HOMA-IR in both 60%T (P=0.041) and 70%T (P=0.002) were lower than Ctr, but not different from 40%T (HOMA-IR: Ctr=3.05±0.40, 40%T=2.67±0.35, 60%T=2.49±0.31, 70%T=2.21±0.27). The results suggest that for physically inactive individuals with metabolic syndrome, exercising at low to moderate intensity may be sufficient to attenuate PPL and increase insulin sensitivity, whereas higher intensity exercise may be needed to normalize blood glucose. Springer-Verlag, 2006 Acute exercise nationallicence Triglyceride nationallicence Insulin resistance nationallicence HOMA-IR nationallicence Zhang John Department of Health and Kinesiology, University of Texas-San Antonio, 6900 North Loop, 1604 West, 78249, San Antonio, TX, USA aut Ji Lisa Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX, USA aut Fretwell Vicki Department of Health and Kinesiology, University of Texas-San Antonio, 6900 North Loop, 1604 West, 78249, San Antonio, TX, USA aut Nunez Guadalupe Department of Health and Kinesiology, University of Texas-San Antonio, 6900 North Loop, 1604 West, 78249, San Antonio, TX, USA aut European Journal of Applied Physiology Springer-Verlag 98/6(2006-12-01), 575-582 1439-6319 98:6<575 2006 98 421 https://doi.org/10.1007/s00421-006-0304-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0304-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang John Department of Health and Kinesiology, University of Texas-San Antonio, 6900 North Loop, 1604 West, 78249, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Ji Lisa Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Fretwell Vicki Department of Health and Kinesiology, University of Texas-San Antonio, 6900 North Loop, 1604 West, 78249, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Nunez Guadalupe Department of Health and Kinesiology, University of Texas-San Antonio, 6900 North Loop, 1604 West, 78249, San Antonio, TX, USA aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 98/6(2006-12-01), 575-582 1439-6319 98:6<575 2006 98 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer