caa a22 4500 467940169 CHVBK 20180406153010.0 cr unu---uuuuu 170328e20061001xx s 000 0 eng 10.1007/s00421-006-0275-9 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0275-9 A comparative scale of autonomic function with age through the tone-entropy analysis on heart period variation [Elektronische Daten] [Masari Amano, Eiichi Oida, Toshio Moritani] Tremendous numbers of heart rate variability studies have aimed to elucidate age-associated alterations of autonomic function in the past decades. However, the studies, far from clarifying ageing mechanisms, fell into confusion by a lack of common scales. The purpose of this study is to show a possibility to establish a comparative scale of autonomic function through a method, tone-entropy (T-E) analysis on heart period variation, whose validity has been already examined on typical physiological cases (Oida et al. in J Appl Physiol 82:1794-1801, 1997; Oida et al. in J Gerontol 54A:M219-M224, 1999a; Oida et al. in Acta Physiol Scand 165:129-134, 1999b; Oida et al. in Acta Physiol Scand 165:421-422, 1999c; Amano et al. in Eur J Appl Physiol 94:602-610, 2005). In this study, 276 subjects from teens to seventies were examined at rest by T-E analysis together with conventional time and frequency domain analyses. The tone (negativity represents vagal predominance) became significantly high [−0.174±0.026 (teens) to −0.024±0.004 (seventies), P<0.05 for one-way ANOVA], and the entropy (total autonomic activity), significantly low [4.40±0.12 (teens) to 2.90±0.09 bit (seventies), P<0.05] with advancing age. The result, plotted in 2-D T-E space, showed that the ageing traced a curvi-linear relation from right-bottom to left-top, and was consistent with previously studied typical physiological cases. The conventional analyses showed almost the same autonomic reduction as T-E did, but failed in detecting delicate alteration of autonomic balance. The results, showing that autonomic activity reduced in both pathways impairing vagal predominance significantly with ageing, suggested a possibility to assess autonomic function in 2-D T-E space in a comparative way. Springer-Verlag, 2006 Autonomic nervous system nationallicence Heart rate variability nationallicence Spectral analysis nationallicence Sympatho-vagal balance nationallicence Amano Masari Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, 606-8501, Kyoto, Japan aut Oida Eiichi Department of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 612-8555, Kyoto, Japan aut Moritani Toshio Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, 606-8501, Kyoto, Japan aut European Journal of Applied Physiology Springer-Verlag 98/3(2006-10-01), 276-283 1439-6319 98:3<276 2006 98 421 https://doi.org/10.1007/s00421-006-0275-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0275-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Amano Masari Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, 606-8501, Kyoto, Japan aut NATIONALLICENCE 700 1- Oida Eiichi Department of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 612-8555, Kyoto, Japan aut NATIONALLICENCE 700 1- Moritani Toshio Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, 606-8501, Kyoto, Japan aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 98/3(2006-10-01), 276-283 1439-6319 98:3<276 2006 98 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer